Spatial transcriptomics reveals tumor niche heterogeneity in advanced gastric cancer and suggests a tumor-promoting role for KRT6B

doi:10.4251/wjgo.121446

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Sep 15, 2026; 18(9): 121446
Published online Sep 15, 2026. doi: 10.4251/wjgo.121446

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Figure 2 Spatial niches identification and characterization using BANKSY. A: UMAP of integrated P2 and P4 spatial transcriptomic data. Left: Spots colored by sample (P2, red; P4, blue). Right: Spots colored by BANKSY-defined niche identities (N0-N12); B: Spatial maps of BANKSY-defined niches (N0-N12) in P2 (left) and P4 (right); C: Bar plots showing the number of spots assigned to each first-weight cell type within each niche in P2 (top) and P4 (bottom). Colors denote different cell types; D: Spatial localization of each niche in P2 (top) and P4 (bottom), with red indicating spatial regions assigned to each niche.

Citation: Ni R, Dong H, Han RD, Ren XC, Qu YL, Wang L, Chen SS, Zhang YC. Spatial transcriptomics reveals tumor niche heterogeneity in advanced gastric cancer and suggests a tumor-promoting role for KRT6B. World J Gastrointest Oncol 2026; 18(9): 121446
URL: https://www.wjgnet.com/1948-5204/full/v18/i9/121446.htm
DOI: https://dx.doi.org/10.4251/wjgo.121446

Ni R, Dong H, Han RD, Ren XC, Qu YL, Wang L, Chen SS, Zhang YC. Spatial transcriptomics reveals tumor niche heterogeneity in advanced gastric cancer and suggests a tumor-promoting role for KRT6B. World J Gastrointest Oncol 2026; 18(9): 121446 [DOI: 10.4251/wjgo.121446]

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