Targeting cyclin-dependent kinase 6 partially reverses drug resistance in ripretinib-resistant gastrointestinal stromal tumor cells in vitro

doi:10.4251/wjgo.121282

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Sep 15, 2026; 18(9): 121282
Published online Sep 15, 2026. doi: 10.4251/wjgo.121282

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Figure 5 The effect of cyclin-dependent kinase 6 on the cell cycle of gastrointestinal stromal tumor cells. In the T1, 882, and 430 cell lines, cyclin-dependent kinase 6 inhibitors had no significant effect on the cell cycle. However, in the ripretinib-resistant cell lines T1 resistance index (RI), 882RI, and 430RI, cyclin-dependent kinase 6 inhibitors significantly increased the proportion of cells in the G1 phase. P: Palbociclib; Ri: Ripretinib; RI: Resistance index.

Citation: Wang XD, Shou CH, Chen SC, Hong YY, Zhu KK, Yang WL, Yu JR. Targeting cyclin-dependent kinase 6 partially reverses drug resistance in ripretinib-resistant gastrointestinal stromal tumor cells in vitro. World J Gastrointest Oncol 2026; 18(9): 121282
URL: https://www.wjgnet.com/1948-5204/full/v18/i9/121282.htm
DOI: https://dx.doi.org/10.4251/wjgo.121282

Wang XD, Shou CH, Chen SC, Hong YY, Zhu KK, Yang WL, Yu JR. Targeting cyclin-dependent kinase 6 partially reverses drug resistance in ripretinib-resistant gastrointestinal stromal tumor cells in vitro. World J Gastrointest Oncol 2026; 18(9): 121282 [DOI: 10.4251/wjgo.121282]

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