Risk factors for recurrence and metastasis of stage IIIC colorectal cancer: A two-center retrospective cohort study

doi:10.4251/wjgo.121235

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Sep 15, 2026; 18(9): 121235
Published online Sep 15, 2026. doi: 10.4251/wjgo.121235

Table 2 Multivariate analysis of risk factors for postoperative recurrence or metastasis in stage IIIC colorectal cancer

Variable	B	SE	Wald χ²	P value	HR	95%CI
Age (year)	0.217	0.214	1.031	0.310	1.242	0.817-1.888
CEA (μg/L)	0.626	0.199	9.909	0.002	1.871	1.267-2.763
CA19-9 (kU/L)	0.290	0.203	2.042	0.153	1.337	0.898-1.990
Neural invasion	0.196	0.220	0.797	0.372	1.217	0.791-1.873
PRL	0.471	0.205	5.292	0.021	1.602	1.072-2.393
MLR	0.757	0.219	11.945	0.001	2.132	1.388-3.275
pT stage			5.381	0.068
T4a vs T3	0.532	0.234	5.143	0.023	1.702	1.075-2.694
T4b vs T3	0.556	0.416	1.787	0.181	1.744	0.772-3.944

CEA: Carcinoembryonic antigen; CA19-9: Carbohydrate antigen 19-9; PRL: Positive root lymph node; MLR: Metastatic lymph node ratio; pT: Pathological T.

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Citation: Ruan Z, Zhu LX, Zeng YY, Lu CH, Guan GX, Wu JW, Li F. Risk factors for recurrence and metastasis of stage IIIC colorectal cancer: A two-center retrospective cohort study. World J Gastrointest Oncol 2026; 18(9): 121235
URL: https://www.wjgnet.com/1948-5204/full/v18/i9/121235.htm
DOI: https://dx.doi.org/10.4251/wjgo.121235

Ruan Z, Zhu LX, Zeng YY, Lu CH, Guan GX, Wu JW, Li F. Risk factors for recurrence and metastasis of stage IIIC colorectal cancer: A two-center retrospective cohort study. World J Gastrointest Oncol 2026; 18(9): 121235 [DOI: 10.4251/wjgo.121235]

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