Clinical and pathological features and treatment of nine cases of gastrointestinal composite gangliocytoma/neuroma and neuroendocrine tumor

Figure 4 Pathological and immunohistochemical features of rectal composite gangliocytoma/neuroma and neuroendocrine tumor. A: Pathological features of the lesion under low-power magnification (hematoxylin and eosin); B: High-power view showing intermingled growth of spindle cells and epithelioid cells with scattered ganglion cells (hematoxylin and eosin); C: Immunohistochemical (IHC) staining for chromogranin A: Strong cytoplasmic positivity in ganglion-like cells with focal weak positivity in epithelioid cells; D: IHC staining for S-100: Cytoplasmic and nuclear positivity in spindle cells, with negative expression in epithelioid and ganglion-like cells; E: IHC staining for Ki-67: Low proliferative index; F: IHC staining for synaptophysin: Focal cytoplasmic positivity in epithelioid and ganglion-like cells.