Clinical and pathological features and treatment of nine cases of gastrointestinal composite gangliocytoma/neuroma and neuroendocrine tumor

Figure 3 Pathological and immunohistochemical features of composite gangliocytoma/neuroma and neuroendocrine tumor (from the patient shown in the previous computed tomography images). A: Pathological features of the lesion under low-power magnification (hematoxylin and eosin); B: High-power view showing spindle-shaped tumor cells arranged in fascicular sheets, nested pseudoglandular epithelioid tumor cells, and scattered ganglion-like cells with distinct nuclear membranes and prominent nucleoli (hematoxylin and eosin); C: Immunohistochemical (IHC) staining for pan-cytokeratin: Cytoplasmic positivity in epithelioid cells, with negative expression in spindle cells and ganglion-like cells; D: IHC staining for S-100: Nuclear positivity in spindle-shaped Schwann cells, with negative expression in epithelioid cells; E: IHC staining for SOX10: Nuclear positivity in spindle cells, with negative expression in epithelioid cells (in the lower right corner); F: IHC staining for synaptophysin: Diffuse cytoplasmic positivity in epithelioid cells and ganglion-like cells.