Comparative study of 18F-FAPI-04 and 18F-FDG PET/CT in the initial staging and postoperative metastasis detection of gastric cancer

doi:10.4251/wjgo.120559

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World Journal of Gastrointestinal Oncology

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1948-5204

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World J Gastrointest Oncol. Sep 15, 2026; 18(9): 120559
Published online Sep 15, 2026. doi: 10.4251/wjgo.120559

Table 4 Diagnostic performance of ¹⁸F-fibroblast activation protein inhibitor-04 and ¹⁸F-fluorodeoxyglucos uptake in various lesions

Lesions	Tracer	No. of TP	No. of TN	No. of FN	Sen (%)	95%CI	NPV (%)
Primary tumors	¹⁸F-FAPI-04	11	0	0	100%	0.717-1.0	N/A
Primary tumors	¹⁸F-FDG	10	0	1	90.9%	0.623-0.984	N/A
LNM	¹⁸F-FAPI-04	8	1	0	100%	0.678-1.0	100%
LNM	¹⁸F-FDG	6	1	2	75%	0.409-0.928	33.3%
BM	¹⁸F-FAPI-04	1	0	1	N/A	N/A	N/A
BM	¹⁸F-FDG	1	0	1	N/A	N/A	N/A
PM	¹⁸F-FAPI-04	6	0	0	100%	0.610-1.0	N/A
PM	¹⁸F-FDG	3	0	3	50%	0.188-0.812	N/A
LM	¹⁸F-FAPI-04	1	0	1	N/A	N/A	N/A
LM	¹⁸F-FDG	1	0	1	N/A	N/A	N/A
LR	¹⁸F-FAPI-04	1	0	0	N/A	N/A	N/A
LR	¹⁸F-FDG	1	0	0	N/A	N/A	N/A

¹⁸F-FAPI-04: ¹⁸F-fibroblast activation protein inhibitor-04; ¹⁸F-FDG: ¹⁸F-fluorodeoxyglucos; CI: Confidence interval; TP: True positive; TN: True negative; FN: False negative; NPV: Negative-predictive value; Sen: Sensitivity; LR: Local recurrences; LNM: Lymph node metastases; BM: Bone metastases; LM: Liver metastases; PM: Peritoneal metastases; N/A: Not applicable. Sensitivity not reported because only 1 true positive case was identified for this lesion type; any calculated sensitivity (50% or 100%) would be statistically unstable and clinically uninformative.

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Citation: Xue XQ, Li QB, Fu HT, Hou L, Wang R, Shi X, Yu CJ. Comparative study of ¹⁸F-FAPI-04 and ¹⁸F-FDG PET/CT in the initial staging and postoperative metastasis detection of gastric cancer. World J Gastrointest Oncol 2026; 18(9): 120559
URL: https://www.wjgnet.com/1948-5204/full/v18/i9/120559.htm
DOI: https://dx.doi.org/10.4251/wjgo.120559

Xue XQ, Li QB, Fu HT, Hou L, Wang R, Shi X, Yu CJ. Comparative study of ¹⁸F-FAPI-04 and ¹⁸F-FDG PET/CT in the initial staging and postoperative metastasis detection of gastric cancer. World J Gastrointest Oncol 2026; 18(9): 120559 [DOI: 10.4251/wjgo.120559]

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