IQGAP1 promotes tumor progression by stabilizing MCM3/Nrf2 in cholangiocarcinoma

doi:10.4251/wjgo.120170

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Sep 15, 2026; 18(9): 120170
Published online Sep 15, 2026. doi: 10.4251/wjgo.120170

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Figure 7 IQGAP1 promoted the proliferation and migration of cholangiocarcinoma by regulating MCM3 in vivo. A-C: Subcutaneous xenografts from three groups of differently treated cells. Subcutaneous tumor volume and weight were largest in the presence of IQGAP1, and this was MCM3 dependent; D: Ki-67, IQGAP1, and MCM3 histochemical staining of xenografts. ^aP < 0.0001. NC: Negative control; HE: Hematoxylin and eosin.

Citation: Ren ZY, Zhang HY, Xie CX, Zhou GP, Chen PY, Yuan H, Zhang K, Xu Y, Wang YY, Chen TY, Li QS, Yu HB. IQGAP1 promotes tumor progression by stabilizing MCM3/Nrf2 in cholangiocarcinoma. World J Gastrointest Oncol 2026; 18(9): 120170
URL: https://www.wjgnet.com/1948-5204/full/v18/i9/120170.htm
DOI: https://dx.doi.org/10.4251/wjgo.120170

Ren ZY, Zhang HY, Xie CX, Zhou GP, Chen PY, Yuan H, Zhang K, Xu Y, Wang YY, Chen TY, Li QS, Yu HB. IQGAP1 promotes tumor progression by stabilizing MCM3/Nrf2 in cholangiocarcinoma. World J Gastrointest Oncol 2026; 18(9): 120170 [DOI: 10.4251/wjgo.120170]

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