IQGAP1 promotes tumor progression by stabilizing MCM3/Nrf2 in cholangiocarcinoma

doi:10.4251/wjgo.120170

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Sep 15, 2026; 18(9): 120170
Published online Sep 15, 2026. doi: 10.4251/wjgo.120170

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Figure 6 IQGAP1 promoted the progression of cholangiocarcinoma by regulating MCM3. A and B: TUNEL staining results and flow cytometry analysis showed that the cell apoptosis inhibited by overexpression (OE) of IQGAP1 could be restored by knocking down MCM3; C-G: HUCCT1 transfected with OE of IQGAP1 showed higher proliferative capacity compared with NC in cell counting kit-8, plate cloning, 5-ethynyl-2’-deoxyuridine, Transwell and wound healing tests which was restored when MCM3 was knocked down. ^aP < 0.001. NC: Negative control; OE: Overexpression; si: Silence; EdU: 5-ethynyl-2’-deoxyuridine; OD: Optical density.

Citation: Ren ZY, Zhang HY, Xie CX, Zhou GP, Chen PY, Yuan H, Zhang K, Xu Y, Wang YY, Chen TY, Li QS, Yu HB. IQGAP1 promotes tumor progression by stabilizing MCM3/Nrf2 in cholangiocarcinoma. World J Gastrointest Oncol 2026; 18(9): 120170
URL: https://www.wjgnet.com/1948-5204/full/v18/i9/120170.htm
DOI: https://dx.doi.org/10.4251/wjgo.120170

Ren ZY, Zhang HY, Xie CX, Zhou GP, Chen PY, Yuan H, Zhang K, Xu Y, Wang YY, Chen TY, Li QS, Yu HB. IQGAP1 promotes tumor progression by stabilizing MCM3/Nrf2 in cholangiocarcinoma. World J Gastrointest Oncol 2026; 18(9): 120170 [DOI: 10.4251/wjgo.120170]

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