IQGAP1 promotes tumor progression by stabilizing MCM3/Nrf2 in cholangiocarcinoma

Figure 1 IQGAP1 was upregulated in cholangiocarcinoma tissues. A: Venn diagram of differential genes shared by four public databases. The transcriptome data of cholangiocarcinoma (CCA) in this study were sourced from four publicly available authoritative databases: (1) The Cancer Genome Atlas (TCGA) database’s TCGA-CHOL cohort, which included RNA-seq data from 36 CCA tumor tissues and 9 paired normal bile duct tissues; (2) The Gene Expression Omnibus (GEO) database’s GSE76297 dataset, constructed based on the GPL17586 platform, which included chip data from 54 CCA tumor tissues and 53 paired non-tumor tissues; (3) The GEO database’s GSE26566 dataset, constructed based on the GPL6104 platform, which included chip data from 104 CCA tumor tissues and 65 control tissues; and (4) The GEO database’s GSE32879 dataset, constructed based on the GPL6244 platform, which included chip data from 16 introhepatic CCA tumor tissues and 7 normal liver tissues. All datasets were standardized and quality-controlled to ensure the comparability and reliability of the data; B: The intersection of common differential genes with the top ten genes in the GSE76296 database; C: The mRNA expression of IQGAP1 tissue in different types of cancer in Tumor Immune Estimation Resource 2.0; D-G: The mRNA expression of IQGAP1 in different databases. ^aP < 0.05; ^bP < 0.01; ^cP < 0.001; ^dP < 0.0001. TCGA: The Cancer Genome Atlas; TPM: Transcripts per million.