Integrated diagnostic model based on serum exosomal microRNAs and functional mechanism of miR-200b-3p in hepatocellular carcinoma

Figure 7 MiR-200b-3p suppresses the malignant phenotypes of hepatocellular carcinoma cells. A-D: CCK-8 assays and cell colony formation assay (n = 3) indicated that overexpression of miR-200b-3p suppressed hepatocellular carcinoma cell proliferation, whereas its knockdown enhanced proliferative capacity; E and F: Wound healing assays (n = 3) demonstrated that miR-200b-3p knockdown accelerated wound closure, while its overexpression impeded cell migration; G: In Matrigel invasion assays (n = 3), silencing of miR-200b-3p promoted cellular invasion, in contrast to the suppressive effect observed upon miR-200b-3p overexpression. ^aP < 0.05, ^bP < 0.01, and ^cP < 0.001. NC: Normal control; OE: Overexpression; SP: Sponge.