Expression of tensin 4 in hepatocellular carcinoma and its role in epithelial-mesenchymal transformation

doi:10.4251/wjgo.123710

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World Journal of Gastrointestinal Oncology

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1948-5204

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Aug 15, 2026; 18(8): 123710
Published online Aug 15, 2026. doi: 10.4251/wjgo.123710

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Figure 12 Effects of transforming growth factor-β1/Smad pathway inhibitor small-molecule inhibitor of Smad3 on epithelial-mesenchymal transition-related protein expression in HepG2 and PLC cells. A: Effects of transforming growth factor (TGF)-β1/Smad pathway inhibitor small-molecule inhibitor of Smad3 (SIS3) on epithelial-mesenchymal transition-related protein expression in HepG2 cells, measured by western blotting; B-E: SIS3 significantly downregulated expression of N-cadherin, vimentin and Slug, and significantly upregulated expression of E-cadherin in HepG2 cells; F: Effects of transforming growth factor-β1/Smad pathway inhibitor SIS3 on epithelial-mesenchymal transition-related protein expression in PLC cells, measured by western blotting; G-J: SIS3 significantly downregulated expression of N-cadherin, vimentin and Slug, and significantly upregulated expression of E-cadherin in PLC cells. ^cP < 0.001, ^dP < 0.0001. TGF-β1: Transforming growth factor-β1; TNS4: Tensin 4; OE: Overexpression; AAV8: Adeno-associated virus 8; SIS3: Small-molecule inhibitor of Smad3.

Citation: Chen GL, Liu JH. Expression of tensin 4 in hepatocellular carcinoma and its role in epithelial-mesenchymal transformation. World J Gastrointest Oncol 2026; 18(8): 123710
URL: https://www.wjgnet.com/1948-5204/full/v18/i8/123710.htm
DOI: https://dx.doi.org/10.4251/wjgo.123710

Chen GL, Liu JH. Expression of tensin 4 in hepatocellular carcinoma and its role in epithelial-mesenchymal transformation. World J Gastrointest Oncol 2026; 18(8): 123710 [DOI: 10.4251/wjgo.123710]

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