Expression of tensin 4 in hepatocellular carcinoma and its role in epithelial-mesenchymal transformation

Figure 10  Relationship between Slug knockdown after overexpression of tensin 4 and epithelial-mesenchymal transition of HepG2 and PLC cell lines. A: Relationship between Slug knockdown after tensin (TNS) 4 overexpression (OE) and epithelial-mesenchymal transition in HepG2 cells; B-D: After OE of TNS4, Slug knockdown significantly upregulated expression of E-cadherin, and significantly downregulated expression of N-cadherin and vimentin in HepG2 cells; E: Relationship between Slug knockdown after TNS4 OE and epithelial-mesenchymal transition in PLC cells line; F-H: After OE of TNS4, Slug knockdown significantly upregulated expression of E-cadherin, and significantly downregulated expression of N-cadherin and vimentin in PLC cells. ^bP < 0.01, ^dP < 0.0001. TGF-β1: Transforming growth factor-β1; OE: Overexpression; TNS4: Tensin 4.