Expression of tensin 4 in hepatocellular carcinoma and its role in epithelial-mesenchymal transformation

Figure 9 Effects of transforming growth factor-β1+ overexpression of tensin 4 on epithelial-mesenchymal transition-related protein expression in HepG2 and PLC cells. A: Effect of transforming growth factor (TGF)-β1 + overexpression (OE) of tensin (TNS) 4 on epithelial-mesenchymal transition (EMT)-related protein expression in HepG2 cells, measured by western blotting; B-E: TGF-β1 + OE significantly upregulated expression of N-cadherin, vimentin and Slug, and downregulated E-cadherin expression in HepG2 cells; F: Effect of TGF-β1 + OE of TNS4 on EMT-related protein expression in PLC cells, measured by western blotting; G-J: TGF-β1 + OE exerted consistent regulatory effects on the aforementioned EMT-related proteins in PLC cells. ^cP < 0.001, ^dP < 0.0001. TGF-β1: Transforming growth factor-β1; OE: Overexpression; TNS4: Tensin 4.