Expression of tensin 4 in hepatocellular carcinoma and its role in epithelial-mesenchymal transformation

Figure 6 Effects of tensin 4-shRNA transfection on epithelial-mesenchymal transition-related protein expression in HepG2 and PLC cells. A: Influence of tensin (TNS)4-shRNA transfection on epithelial-mesenchymal transition-related protein expression in HepG2 cells, measured by western blotting; B-E: TNS4-shRNA1 transfection significantly downregulated expression of N-cadherin, vimentin and Slug, and upregulated E-cadherin expression in HepG2 cells; F: Influence of TNS4-shRNA transfection on epithelial-mesenchymal transition-related protein expression in PLC cells, measured by western blotting; G-J: TNS4-shRNA1 transfection exerted consistent regulatory effects in PLC cells, with downregulation of N-cadherin, vimentin and Slug and upregulation of E-cadherin. ^bP < 0.01, ^cP < 0.001, ^dP < 0.0001. TNS4: Tensin 4; AAV: Adeno-associated virus.