Relationship of TRAP1, HMGB1, and p62 expression with clinicopathologic features in colon cancer tissues

doi:10.4251/wjgo.123088

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Aug 15, 2026; 18(8): 123088
Published online Aug 15, 2026. doi: 10.4251/wjgo.123088

Table 8 Multivariable Cox regression analysis of overall survival in patients with colon cancer

Variable	B	SE	HR	95%CI	P value
Age ≥ 60 years	0.412	0.391	1.51	0.70-3.27	0.292
Poor differentiation	0.603	0.428	1.83	0.79-4.24	0.158
LNM positive	0.998	0.415	2.71	1.20-6.10	0.016
LVI positive	0.806	0.405	2.24	1.01-4.94	0.047
High TRAP1 expression	1.061	0.412	2.89	1.29-6.48	0.010
High HMGB1 expression	0.562	0.398	1.75	0.80-3.83	0.157
High p62 expression	0.478	0.387	1.61	0.75-3.45	0.216

LNM: Lymph node metastasis; LVI: Lymphovascular invasion; HR: Hazard ratio; CI: Confidence interval.

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Citation: Guo HL, Qi YP, Zhang Q, Hao JJ, Yang Y, Zhang MY, He ZT. Relationship of TRAP1, HMGB1, and p62 expression with clinicopathologic features in colon cancer tissues. World J Gastrointest Oncol 2026; 18(8): 123088
URL: https://www.wjgnet.com/1948-5204/full/v18/i8/123088.htm
DOI: https://dx.doi.org/10.4251/wjgo.123088

Guo HL, Qi YP, Zhang Q, Hao JJ, Yang Y, Zhang MY, He ZT. Relationship of TRAP1, HMGB1, and p62 expression with clinicopathologic features in colon cancer tissues. World J Gastrointest Oncol 2026; 18(8): 123088 [DOI: 10.4251/wjgo.123088]

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