Relationship of TRAP1, HMGB1, and p62 expression with clinicopathologic features in colon cancer tissues

Table 6 Relationship between p62 expression and clinicopathologic characteristics in colon cancer, n (%)

Clinicopathologic variable	Low p62	High p62	P value
Age < 60 years	24 (57.1)	18 (42.9)	0.878
Age ≥ 60 years	42 (53.8)	36 (46.2)
Male	36 (52.2)	33 (47.8)	0.590
Female	30 (58.8)	21 (41.2)
Right colon	27 (57.4)	20 (42.6)	0.807
Left colon	39 (53.4)	34 (46.6)
Maximum tumor diameter < 5 cm	35 (60.3)	23 (39.7)	0.340
Maximum tumor diameter ≥ 5 cm	31 (50.0)	31 (50.0)
Well/moderately differentiated	52 (61.9)	32 (38.1)	0.034
Poorly differentiated	14 (38.9)	22 (61.1)
Depth of invasion T1-2	18 (62.1)	11 (37.9)	0.506
Depth of invasion T3-4	48 (52.7)	43 (47.3)
LNM (-)	42 (65.6)	22 (34.4)	0.020
LNM (+)	24 (42.9)	32 (57.1)
TNM stage I-II	43 (71.7)	17 (28.3)	< 0.001
TNM stage III-IV	23 (38.3)	37 (61.7)
LVI (-)	49 (59.8)	33 (40.2)	0.180
LVI (+)	17 (44.7)	21 (55.3)
PNI (-)	52 (57.1)	39 (42.9)	0.534
PNI (+)	14 (48.3)	15 (51.7)

High p62 expression was mainly associated with differentiation, lymph node metastasis, and tumor-node-metastasis stage.

LNM: Lymph node metastasis; TNM: Tumor-node-metastasis; LVI: Lymphovascular invasion; PNI: Perineural invasion.