Relationship of TRAP1, HMGB1, and p62 expression with clinicopathologic features in colon cancer tissues

Table 5 Relationship between HMGB1 expression and clinicopathologic characteristics in colon cancer, n (%)

Clinicopathologic variable	Low HMGB1	High HMGB1	P value
Age < 60 years	24 (57.1)	18 (42.9)	0.491
Age ≥ 60 years	38 (48.7)	40 (51.3)
Male	35 (50.7)	34 (49.3)	0.956
Female	27 (52.9)	24 (47.1)
Right colon	24 (51.1)	23 (48.9)	1.000
Left colon	38 (52.1)	35 (47.9)
Maximum tumor diameter < 5 cm	33 (56.9)	25 (43.1)	0.354
Maximum tumor diameter ≥ 5 cm	29 (46.8)	33 (53.2)
Well/moderately differentiated	49 (58.3)	35 (41.7)	0.042
Poorly differentiated	13 (36.1)	23 (63.9)
Depth of invasion T1-2	20 (69.0)	9 (31.0)	0.054
Depth of invasion T3-4	42 (46.2)	49 (53.8)
LNM (-)	40 (62.5)	24 (37.5)	0.018
LNM (+)	22 (39.3)	34 (60.7)
TNM stage I-II	41 (68.3)	19 (31.7)	< 0.001
TNM stage III-IV	21 (35.0)	39 (65.0)
LVI (-)	46 (56.1)	36 (43.9)	0.219
LVI (+)	16 (42.1)	22 (57.9)
PNI (-)	48 (52.7)	43 (47.3)	0.837
PNI (+)	14 (48.3)	15 (51.7)

HMGB1 was mainly associated with differentiation, lymph node metastasis, and tumor-node-metastasis stage.

LNM: Lymph node metastasis; TNM: Tumor-node-metastasis; LVI: Lymphovascular invasion; PNI: Perineural invasion.