Relationship of TRAP1, HMGB1, and p62 expression with clinicopathologic features in colon cancer tissues

doi:10.4251/wjgo.123088

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World Journal of Gastrointestinal Oncology

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1948-5204

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World J Gastrointest Oncol. Aug 15, 2026; 18(8): 123088
Published online Aug 15, 2026. doi: 10.4251/wjgo.123088

Table 4 Relationship between TRAP1 expression and clinicopathologic characteristics in colon cancer, n (%)

Clinicopathologic variable	Low TRAP1	High TRAP1	χ²	P value
Age < 60 years	22 (52.4)	20 (47.6)	0.617	0.432
Age ≥ 60 years	35 (44.9)	43 (55.1)
Male	31 (44.9)	38 (55.1)	0.431	0.512
Female	26 (51.0)	25 (49.0)
Right colon	23 (48.9)	24 (51.1)	0.064	0.800
Left colon	34 (46.6)	39 (53.4)
Maximum tumor diameter < 5 cm	36 (62.1)	22 (37.9)	9.555	0.002
Maximum tumor diameter ≥ 5 cm	21 (33.9)	41 (66.1)
Well/moderately differentiated	47 (56.0)	37 (44.0)	8.022	0.005
Poorly differentiated	10 (27.8)	26 (72.2)
Depth of invasion T1-2	20 (69.0)	9 (31.0)	7.066	0.008
Depth of invasion T3-4	37 (40.7)	54 (59.3)
LNM (-)	42 (65.6)	22 (34.4)	18.067	<0.001
LNM (+)	15 (26.8)	41 (73.2)
TNM stage I-II	40 (66.7)	20 (33.3)	17.678	<0.001
TNM stage III-IV	17 (28.3)	43 (71.7)
LVI (-)	46 (56.1)	36 (43.9)	7.676	0.006
LVI (+)	11 (28.9)	27 (71.1)
PNI (-)	48 (52.7)	43 (47.3)	4.158	0.041
PNI (+)	9 (31.0)	20 (69.0)

LNM: Lymph node metastasis; TNM: Tumor-node-metastasis; LVI: Lymphovascular invasion; PNI: Perineural invasion.

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Citation: Guo HL, Qi YP, Zhang Q, Hao JJ, Yang Y, Zhang MY, He ZT. Relationship of TRAP1, HMGB1, and p62 expression with clinicopathologic features in colon cancer tissues. World J Gastrointest Oncol 2026; 18(8): 123088
URL: https://www.wjgnet.com/1948-5204/full/v18/i8/123088.htm
DOI: https://dx.doi.org/10.4251/wjgo.123088

Guo HL, Qi YP, Zhang Q, Hao JJ, Yang Y, Zhang MY, He ZT. Relationship of TRAP1, HMGB1, and p62 expression with clinicopathologic features in colon cancer tissues. World J Gastrointest Oncol 2026; 18(8): 123088 [DOI: 10.4251/wjgo.123088]

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