Advances in molecular mechanism of gastric cancer peritoneal metastasis

Table 5 Summary of non-coding RNAs involved in gastric cancer peritoneal metastasis

ncRNA	Location	Association with GC	Targeted genes and pathways	Application
CircPTBP3[140]	Plasma with GC, peritoneal metastasis and cell lines	Promote MMT	SGK1	Diagnostic and therapeutic, potential
lncRNA BDNF-AS[150]	Primary and peritoneal metastatic GC tissue	Inhibit ferroptosis	FBXW7	Prognosis and therapeutic, potential
lncRNA SEMA3B-AS1[193]	Primary and peritoneal metastatic GC tissue	Promote ubiquitination	FBXW7	Tumor suppressor
lncRNA-PMAN[92]	Peritoneal metastatic GC tissue	Inhibit ferroptosis	SLC7A11	Prognosis and therapeutic, potential
LINC00924[148]	GC cells	Lipid metabolism remodeling	Mnk2	Potential therapeutic effector
lncRNA CASC15[194]	Primary and peritoneal metastatic GC tissue	Promote EMT	JNK and p38	Predicting recurrence
lncRNA SNHG12[195]	Extracellular vesicles	Promote HPMC apoptosis and MMT	MAPK/ERK	Potential therapeutic target
lncRNA CTSLP4[196]	GC tissue	Suppress MMT	Snail	Tumor suppressor
lncRNA CCAT1[197]	GC tissue	Promote proliferation and metastasis	Bmi-1	Potential therapeutic target
lncRNA-HOXA11[198]	GC cells	Promote MMT	PDGF BB and TGF β1	Potential therapeutic target
miR-193a-3p[128]	Primary and peritoneal metastatic	Promote proliferation and metastasis	LAMC1	Tumor suppressor
miR-466[199]	GC tissue	Inhibit proliferation, migration and invasion	Unknown	Tumor suppressor
has-let-7 g-3p and has-miR-10395-3p[200]	Samples from peritoneal lavage	Promote metastasis and chemotherapy resistance	Unknown	Predicting peritoneal metastasis and the efficacy of chemotherapy
miR-106a[75]	Exosome	Promote MMT	Smad7 and TIMP2	Potential therapeutic target
miR-136[201]	GC tissue	Inhibit migration and invasion	HOXC10	Tumor suppressor
miR-493[202]	Exosome	Promote chemotherapy resistance	MAD2 L1	Predicting the efficacy of chemotherapy
miR-214[203]	GC cells	Promote proliferation, migration and invasion	PTEN	Potential therapeutic target
miR-21-5p[141]	Exosome	Promote MMT	SMAD7	Potential therapeutic target
miR-106a[204]	Exosome	Promote MMT	SMAD7	Potential therapeutic target
miR-22[143]	GC tissue	Inhibit ECM remodeling and EMT	MMP14 and Snail	Tumor suppressor
miR-30a[205]	GC tissue	Inhibit migration	FAPα	Tumor suppressor
miR-93-5p[142]	GC tissue	Promote proliferation, migration and invasion	IFNAR1	Potential therapeutic target
miR-544[206]	Extracellular vesicles	Promote migration and invasion	PLZF	Potential diagnostic and therapeutic targets
miR-196a-5p[207]	Exosome	Promote MMT	FBXO45	Potential therapeutic target
miR-199a-3p[208]	Primary and peritoneal metastatic GC tissue	Promote EMT	DDR2	Potential therapeutic target
miR-338-3p[209]	GC tissue	Inhibit migration	PTP1B	Tumor suppressor
miR-370[210]	GC tissue	Promote EMT	UQCRC2	Potential therapeutic target

This table catalogs the diverse functions of circular RNAs, long non-coding RNAs, and microRNAs in gastric cancer peritoneal metastasis. It details their cellular or exosomal location, associated mechanisms (e.g., promoting mesothelial-mesenchymal transition, inhibiting ferroptosis), targeted genes/pathways, and their potential applications as diagnostic biomarkers or therapeutic targets. ncRNA: Non-coding RNA; GC: Gastric cancer; circRNAs: Circular RNAs; MMT: Mesothelial-mesenchymal transition; SGK1: Serum and glucocorticoid-regulated kinase 1; lncRNAs: Long non-coding RNAs; BDNF: Brain-derived neurotrophic factor; miRNAs: MicroRNAs; EMT: Epithelial-mesenchymal transition; JNK: Jun N-terminal kinase; HPMC: Human peritoneal mesothelial cell; MAPK: Mitogen-activated protein kinase; PDGF BB: Platelet-derived growth factor-BB; TGF: Transforming growth factor; LAMC1: Laminin gamma 1; TIMP2: Tissue inhibitor of metalloproteinases 2; HOXC10: Homeodomain-containing gene 10; PTEN: Phosphatase and tensin homolog; MMP14: Matrix metallopeptidase 14; FAPα: Fibroblast activation protein alpha; IFNAR1: Interferon (alpha and beta) receptor 1; PLZF: Promyelocytic leukemia zinc finger protein; DDR2: Discoidin domain receptor 2; PTP1B: Protein tyrosine phosphatase 1B; UQCRC2: Ubiquinol-cytochrome c reductase core protein 2.