Cardioprotective effects of remimazolam in elderly hypertensive patients undergoing gastrointestinal tumor surgery: A randomized controlled trial

doi:10.4251/wjgo.v18.i8.121785

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Randomized Controlled Trial

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Aug 15, 2026; 18(8): 121785
Published online Aug 15, 2026. doi: 10.4251/wjgo.v18.i8.121785

Table 9 Comparison of perioperative serum biomarkers of myocardial injury between non-myocardial injury after non-cardiac surgery and myocardial injury after non-cardiac surgery patients, mean ± SD

Item	Time	Non-MINS group (n = 56)	MINS group (n = 24)	t value	P value
hs-cTn (ng/mL)	T0	12.38 ± 12.40	12.58 ± 7.11	-0.077	0.939
	T8	10.80 ± 6.03	16.42 ± 4.42	-4.108	< 0.001
CK (U/L)	T0	44.52 ± 39.38	43.39 ± 34.49	0.121	0.904
	T8	58.66 ± 60.17	83.31 ± 99.74	-1.364	0.176
CK-MB (U/L)	T0	7.15 ± 4.40	8.51 ± 5.58	-1.167	0.247
	T8	7.07 ± 5.03	9.74 ± 5.39	-2.133	0.036
LDH (U/L)	T0	192.13 ± 73.07	180.15 ± 55.89	0.717	0.475
	T8	189.93 ± 75.86	206.18 ± 70.29	-0.897	0.372
AST (U/L)	T0	26.25 ± 30.89	22.66 ± 16.09	0.538	0.592
	T8	23.65 ± 10.89	26.00 ± 19.26	-0.692	0.491
NT-proBNP (pg/mL)	T0	139.27 ± 154.79	158.64 ± 130.65	-0.536	0.593
	T8	334.21 ± 286.67	512.11 ± 312.21	-2.477	0.015

hs-cTn: High-Sensitivity Troponin; CK: Creatine kinase; CK-MB: Creatine kinase-MB; LDH: Lactate dehydrogenase; AST: Aspartate aminotransferase; NT-proBNP: N-terminal pro-brain natriuretic peptide; MINS: Myocardial injury after non-cardiac surgery.

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Citation: Ma TT, Tong J, Liu MY. Cardioprotective effects of remimazolam in elderly hypertensive patients undergoing gastrointestinal tumor surgery: A randomized controlled trial. World J Gastrointest Oncol 2026; 18(8): 121785
URL: https://www.wjgnet.com/1948-5204/full/v18/i8/121785.htm
DOI: https://dx.doi.org/10.4251/wjgo.v18.i8.121785

Ma TT, Tong J, Liu MY. Cardioprotective effects of remimazolam in elderly hypertensive patients undergoing gastrointestinal tumor surgery: A randomized controlled trial. World J Gastrointest Oncol 2026; 18(8): 121785 [DOI: 10.4251/wjgo.v18.i8.121785]

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