Cardioprotective effects of remimazolam in elderly hypertensive patients undergoing gastrointestinal tumor surgery: A randomized controlled trial

doi:10.4251/wjgo.v18.i8.121785

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Randomized Controlled Trial

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Aug 15, 2026; 18(8): 121785
Published online Aug 15, 2026. doi: 10.4251/wjgo.v18.i8.121785

Table 2 Comparison of perioperative serum biomarkers of myocardial injury between the two groups, mean ± SD

Item	Time	P group (n = 40)	R group (n = 40)	t value	P value
hs-cTn (ng/mL)	T0	11.73 ± 14.55	13.15 ± 5.83	-0.575	0.567
	T8	14.73 ± 6.73	10.25 ± 4.55^a	3.483	< 0.001
CK (U/L)	T0	31.96 ± 18.41	56.40 ± 47.37	-3.042	0.003
	T8	68.87 ± 63.87^a	63.24 ± 84.49	0.336	0.738
CK-MB (U/L)	T0	8.41 ± 5.09	6.69 ± 4.36	1.626	0.108
	T8	10.21 ± 5.83^a	5.54 ± 3.27	4.417	< 0.001
LDH (U/L)	T0	186.87 ± 76.69	190.21 ± 59.56	-0.218	0.828
	T8	210.09 ± 88.78^a	179.52 ± 52.75	1.873	0.065
AST (U/L)	T0	23.81 ± 14.79	26.54 ± 35.80	-0.445	0.657
	T8	27.09 ± 16.79	21.62 ± 9.54	1.794	0.077
NT-proBNP (pg/mL)	T0	147.60 ± 144.07	142.56 ± 152.48	0.152	0.880
	T8	490.16 ± 328.72^a	285.00 ± 239.52^a	3.190	0.002

^aP < 0.05 vs T0.

hs-cTn: High-Sensitivity Troponin; CK: Creatine kinase; CK-MB: Creatine kinase-MB; LDH: Lactate dehydrogenase; AST: Aspartate aminotransferase; NT-proBNP: N-terminal pro-brain natriuretic peptide; P group: Control group (propofol-based intravenous general anesthesia); R group: Experimental group (remimazolam-based intravenous general anesthesia).

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Citation: Ma TT, Tong J, Liu MY. Cardioprotective effects of remimazolam in elderly hypertensive patients undergoing gastrointestinal tumor surgery: A randomized controlled trial. World J Gastrointest Oncol 2026; 18(8): 121785
URL: https://www.wjgnet.com/1948-5204/full/v18/i8/121785.htm
DOI: https://dx.doi.org/10.4251/wjgo.v18.i8.121785

Ma TT, Tong J, Liu MY. Cardioprotective effects of remimazolam in elderly hypertensive patients undergoing gastrointestinal tumor surgery: A randomized controlled trial. World J Gastrointest Oncol 2026; 18(8): 121785 [DOI: 10.4251/wjgo.v18.i8.121785]

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