Quantitative TP53 circulating tumor DNA predicts tumor response and survival outcomes in esophageal squamous cell carcinoma

doi:10.4251/wjgo.120942

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Aug 15, 2026; 18(8): 120942
Published online Aug 15, 2026. doi: 10.4251/wjgo.120942

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Figure 6 Multivariable Cox regression analysis of prognostic factors. Multivariate analysis identified high preoperative TP53 circulating tumor DNA variant allele frequency as an independent factor for disease recurrence, alongside advanced tumor-node-metastasis stage. A: Univariate analysis of disease-free survival predictors; B: Multivariate analysis of disease-free survival predictors; C: Univariate analysis of overall survival predictors; D: Multivariate analysis of overall survival predictors. HR: Hazard ratio; CI: Confidence interval; TNM: Tumor-node-metastasis; DFS: Disease-free survival; OS: Overall survival; VAF: Variant allele frequency; ctDNA: Circulating tumor DNA.

Citation: Gu RT, Liu T, Piao ZS, Jin H, Wang XW, Li X. Quantitative TP53 circulating tumor DNA predicts tumor response and survival outcomes in esophageal squamous cell carcinoma. World J Gastrointest Oncol 2026; 18(8): 120942
URL: https://www.wjgnet.com/1948-5204/full/v18/i8/120942.htm
DOI: https://dx.doi.org/10.4251/wjgo.120942

Gu RT, Liu T, Piao ZS, Jin H, Wang XW, Li X. Quantitative TP53 circulating tumor DNA predicts tumor response and survival outcomes in esophageal squamous cell carcinoma. World J Gastrointest Oncol 2026; 18(8): 120942 [DOI: 10.4251/wjgo.120942]

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