Impact of combined pregabalin and multimodal analgesia on cancer pain and quality of life in advanced colorectal cancer

doi:10.4251/wjgo.120486

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Randomized Controlled Trial

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Aug 15, 2026; 18(8): 120486
Published online Aug 15, 2026. doi: 10.4251/wjgo.120486

Table 4 Comparison of the incidence of adverse reactions between the two groups of patients, n (%)

Type of adverse reaction	Observation group (n = 50)	Control group (n = 50)	χ²	P value
Dizziness	12 (24.00)	8 (16.00)	0.98	0.322
Lethargy	10 (20.00)	6 (12.00)	1.15	0.284
Peripheral edema	8 (16.00)	4 (8.00)	1.72	0.190
Constipate	6 (12.00)	18 (36.00)	8.57	< 0.001
Nausea and vomiting	4 (8.00)	14 (28.00)	7.81	0.005
Itchy skin	3 (6.00)	5 (10.00)	0.54	0.463
Overall incidence	23 (46.00)	21 (42.00)	0.16	0.689

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Citation: Wang XY, Wang ZD, Kan K, Guo XX. Impact of combined pregabalin and multimodal analgesia on cancer pain and quality of life in advanced colorectal cancer. World J Gastrointest Oncol 2026; 18(8): 120486
URL: https://www.wjgnet.com/1948-5204/full/v18/i8/120486.htm
DOI: https://dx.doi.org/10.4251/wjgo.120486

Wang XY, Wang ZD, Kan K, Guo XX. Impact of combined pregabalin and multimodal analgesia on cancer pain and quality of life in advanced colorectal cancer. World J Gastrointest Oncol 2026; 18(8): 120486 [DOI: 10.4251/wjgo.120486]

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