Impact of combined pregabalin and multimodal analgesia on cancer pain and quality of life in advanced colorectal cancer

Table 2 Comparison of pain-related indicators between the two groups of patients before and after intervention, mean ± SD

Index	Group	Before intervention	After intervention	t	P value
NRS score (points)	Observation group (n = 50)	6.8 ± 1.2	2.3 ± 0.8	6.92	< 0.001
	Control group (n = 50)	6.7 ± 1.3	3.7 ± 1.0
Number of pain attacks per day	Observation group (n = 50)	2.8 ± 0.9	0.4 ± 0.3	12.15	< 0.001
	Control group (n = 50)	2.7 ± 1.0	1.5 ± 0.6
Average daily dose of opioids (mg OME)	Observation group (n = 50)	185.3 ± 30.5	85.6 ± 20.3	10.38	< 0.001
	Control group (n = 50)	182.7 ± 29.8	132.4 ± 25.6

P < 0.05 for comparisons before and after intervention within the group; oral morphine milligram equivalents is the daily milligram equivalent of oral morphine. NRS: Numerical rating scale; OME: Oral morphine milligram equivalents.