Impact of combined pregabalin and multimodal analgesia on cancer pain and quality of life in advanced colorectal cancer

doi:10.4251/wjgo.120486

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Randomized Controlled Trial

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Aug 15, 2026; 18(8): 120486
Published online Aug 15, 2026. doi: 10.4251/wjgo.120486

Table 1 Comparison of general information between the two groups of patients, n (%)/mean ± SD

Index	Observation group (n = 50)	Control group (n = 50)	χ²/t	P value
Gender			0.16	0.689
Male	28 (56.00)	26 (52.00)
Female	22 (44.00)	24 (48.00)
Age (years)	12.35 ± 4.18	20.46 ± 4.52	2.23	0.028
Disease duration (months)	6.15 ± 2.38	12.58 ± 3.15	0.98	0.328
Sites of tumor metastasis	42.85 ± 5.63	33.67 ± 5.24	0.35	0.951
Liver	23 (46.00)	21 (42.00)
Lung	15 (30.00)	16 (32.00)
Abdominal cavity	8 (16.00)	9 (18.00)
Other	4 (8.00)	4 (8.00)
Baseline NRS score (scores)	26.34 ± 4.15	18.75 ± 3.86	0.38	0.705

NRS: Numerical rating scale.

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Citation: Wang XY, Wang ZD, Kan K, Guo XX. Impact of combined pregabalin and multimodal analgesia on cancer pain and quality of life in advanced colorectal cancer. World J Gastrointest Oncol 2026; 18(8): 120486
URL: https://www.wjgnet.com/1948-5204/full/v18/i8/120486.htm
DOI: https://dx.doi.org/10.4251/wjgo.120486

Wang XY, Wang ZD, Kan K, Guo XX. Impact of combined pregabalin and multimodal analgesia on cancer pain and quality of life in advanced colorectal cancer. World J Gastrointest Oncol 2026; 18(8): 120486 [DOI: 10.4251/wjgo.120486]

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