MCM10 promotes hepatocellular carcinoma progression through cyclin D1 regulation

Figure 5 MCM10 upregulated cyclin D1 expression in hepatocellular carcinoma. A and B: Correlation of MCM10 with cyclin D1 expression in normal tissues and cancer samples based on the data from Genotype Tissue Expression and The Cancer Genome Atlas; C: Representative immunohistochemistry staining of MCM10 and Cyclin D1 in hepatocellular carcinoma (HCC) tissues. Scale bar: 25 μm. n = 147; D: Cyclin D1 expression levels were compared between MCM10 low expression group and MCM10 high expression group; E: Western blot analysis of MCM10 and cyclin D1 expression in 16 freshly collected HCC samples (left). The correlation of MCM10 and cyclin D1 expression is shown on the right; F: Time-dependent receiver operating characteristic curves for either MCM10 or cyclin D1 alone or in combination in predicting overall survival of HCC patients; G and H: Prognostic value of combination of MCM10 and cyclin D1 in overall HCC patients and different subgroups. ^aP < 0.05. TCGA: The Cancer Genome Atlas; GTEx: Genotype Tissue Expression; IHC: Immunohistochemistry; BCLC: Barcelona Clinic Liver Cancer; TBil: Total bilirubin; PT: Prothrombin time; ALB: Albumin.