MCM10 promotes hepatocellular carcinoma progression through cyclin D1 regulation

Figure 4 MCM10 knockdown restrains cell cycle progression by suppressing cyclin D1 expression. A: Gene-set enrichment analysis revealed MCM10 expression significantly and positively correlated with cell cycle-related gene signatures; B and C: Cell cycle analysis of hepatocellular carcinoma (HCC) cells transfected with Lv-shMCM10-1 or Lv-shNC; D: A total of 15 cell cycle-related genes were screened after lentiviral vector transduction; E: Western blot analysis of cyclin D1, CDK4, CDK6, p21, p27, total RB and p-RB in HCC cells after lentiviral vector transduction. Data are represented as mean ± SEM from three independent experiments. ^aP < 0.05, ^bP < 0.01.