MCM10 promotes hepatocellular carcinoma progression through cyclin D1 regulation

Figure 3 MCM10 overexpression promotes hepatocellular carcinoma tumorigenesis in vitro and in vivo. A and B: The mRNA and protein levels of MCM10-overexpressed hepatocellular carcinoma cells and corresponding control cells; C: Cell viability was detected by Cell Counting Kit-8 assay in MCM10-overexpressed cells (Hep3B and HCCLM3); D: Representative images and summary of foci formation in MCM10-overexpressed cells (Hep3B and HCCLM3); E: Cell proliferation was detected by EdU assay in MCM10-overexpressed cells (Hep3B and HCCLM3); F: Representative images and summary of soft agar colony formation in MCM10-overexpressing cells (Hep3B and HCCLM3); G: Subcutaneous tumors formed in nude mice of HCCLM3-MCM10 and control cells (n = 5); H: Tumor growth curves were summarized in the line chart between MCM10-overexpressing cells and control cells; I: The tumor weight of xenografts in nude mice. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001.