MCM10 promotes hepatocellular carcinoma progression through cyclin D1 regulation

Figure 2 MCM10 knockdown inhibits hepatocellular carcinoma tumorigenesis in vitro and in vivo. A and B: The mRNA and protein levels of MCM10-knockdown hepatocellular carcinoma cells and corresponding control cells; C: Cell viability was detected by Cell Counting Kit-8 assay in MCM10-knockdown cells (MHCC97H and SMMC7721); D: Representative images and summary of foci formation in MCM10-knockdown cells (MHCC97H and SMMC7721); E: Cell proliferation was detected by EdU assay in MCM10-knockdown cells (MHCC97H and SMMC7721); F: Representative images and summary of soft agar colony formation in MCM10-knockdown cells (MHCC97H and SMMC7721); G: Subcutaneous tumors formed in nude mice of MHCC97H-shMCM10-1 and shNC cells (n = 6); H: Tumor growth curves were summarized in the line chart between MCM10-knockdown cells and control cells; I: The tumor weight of xenografts was obtained in nude mice. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001.