MCM10 promotes hepatocellular carcinoma progression through cyclin D1 regulation

Figure 1 MCM10 expression is significantly upregulated in hepatocellular carcinoma and indicates poor prognosis. A: Representative immunohistochemistry (IHC) images of MCM10 in human hepatocellular carcinoma (HCC) and nontumor tissues; B: The IHC scores of MCM10 in HCC and nontumor tissues; C: Expression of MCM10 in the immortalized hepatocyte cell line LO2 and seven HCC cell lines (Huh7, Hep3B, HCCLM3, SNU398, HepG2, SMMC7721, and MHCC97H) analyzed by quantitative real-time PCR and western blotting; D and E: The cumulative overall survival differences between patients with low and high MCM10 expression in all patients and different subgroups. ^aP < 0.05, ^cP < 0.001. HCC: Hepatocellular carcinoma; ALT: Alanine aminotransferase; BCLC: Barcelona Clinic Liver Cancer; ALB: Albumin.