Polymerase chain reaction detection of Streptococcus anginosus in digestive diseases and its immunomodulation in rat gastric cancer model

doi:10.4251/wjgo.119026

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Aug 15, 2026; 18(8): 119026
Published online Aug 15, 2026. doi: 10.4251/wjgo.119026

Table 10 Relationship between relative bacterial load of pharyngitis streptococcus and serum interleukin-6, tumor necrosis factor-α levels, and immune cell infiltration score

Indicators	Relative bacterial load of S. anginosus
Indicators	r value	P value
IL-6	0.458	< 0.001
TNF-α	0.469	< 0.001
CD4⁺ T cell infiltration score	0.587	< 0.001
CD8⁺ T cell infiltration score	0.506	< 0.001
CD68⁺ macrophage infiltration score	0.545	< 0.001

Relative bacterial load of Streptococcus anginosus in this section refers to the relative DNA abundance of Streptococcus anginosus detected by speciesspecific quantitative real-time polymerase chain reaction in gastric tumor/adjacent mucosal tissues at the experimental endpoint. IL-6: Interleukin-6; S. anginosus: Streptococcus anginosus; TNF-α: Tumor necrosis factor-α.

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Citation: Huang DB, Chen BS, Wang AP, Hu XZ, Xu YJ. Polymerase chain reaction detection of Streptococcus anginosus in digestive diseases and its immunomodulation in rat gastric cancer model. World J Gastrointest Oncol 2026; 18(8): 119026
URL: https://www.wjgnet.com/1948-5204/full/v18/i8/119026.htm
DOI: https://dx.doi.org/10.4251/wjgo.119026

Huang DB, Chen BS, Wang AP, Hu XZ, Xu YJ. Polymerase chain reaction detection of Streptococcus anginosus in digestive diseases and its immunomodulation in rat gastric cancer model. World J Gastrointest Oncol 2026; 18(8): 119026 [DOI: 10.4251/wjgo.119026]

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