Interaction between calcium channel blockers and capecitabine in colorectal cancer patients with hypertension

Table 4 Results of repeated-measures analysis of variance for blood pressure and tumor markers

Outcome	Effect	F (df)	P value	η²
Systolic blood pressure	Time	32.5 (1118)	0.001	0.216
	Time × group	6.8 (1118)	0.010	0.055
	Group	5.3 (1118)	0.023	0.043
Diastolic blood pressure	Time	25.1 (1118)	0.001	0.175
	Time × group	5.1 (1118)	0.026	0.041
	Group	4.2 (1118)	0.043	0.034
CEA	Time	28.3 (1118)	0.001	0.193
	Time × group	4.0 (1118)	0.048	0.033
	Group	4.1 (1118)	0.046	0.034
CA19-9	Time	34.7 (1118)	0.001	0.227
	Time × group	4.5 (1118)	0.036	0.037
	Group	4.3 (1118)	0.041	0.035

It summarizes the results of the repeated-measures analysis of variance performed to evaluate the effects of time, group, and the time × group interaction on systolic blood pressure, diastolic blood pressure, carcinoembryonic antigen, and carbohydrate antigen 19-9. The analysis reveals significant main effects of time and group, as well as significant time × group interactions for all outcomes (P < 0.05). CEA: Carcinoembryonic antigen; CA19-9: Carbohydrate antigen 19-9.