ASAP3 disrupts ASAP1-ARHGAP12 to inhibit RhoA and yes-associated protein/transcriptional coactivator with PDZ-binding motif, suppressing gastric cancer progression

Figure 5 Underlying mechanisms of ASAP3 in AGS cells using transcriptome sequencing. A: The principal component analysis of the over-expression (oe)-negative control (NC)-AGS and oe-ASAP3-AGS cells; B: The volcano plot of the differential expressed messenger RNAs (DEMs) between the oe-NC-AGS and oe-ASAP3-AGS cells; C: The heatmap of the identified DEMs; D: The Gene Ontology terms enriched by the identified DEMs; E: Kyoto Encyclopedia of Genes and Genomes pathway analysis of the identified DEMs. PCA: Principal component analysis; PC: Principal component; oe: Over-expression; GO: Gene Ontology; KEGG: Kyoto Encyclopedia of Genes and Genomes; BP: Biological process; MF: Molecular function; CC: Cellular component; TNF: Tumor necrosis factor; IL: Interleukin; MAPK: Mitogen-activated protein kinase; NC: Negative control.