TCHP regulates the proliferation and apoptosis of gastric cancer cells via AKT/BCL2 signaling pathway

Figure 5 TCHP knockdown suppresses gastric cancer cell growth in vivo. A: Tumor volumes in mouse xenograft models were compared between negative control (NC) and shTCHP3 groups; B: Tumor growth curves showed the tumor volumes measured every seven days; C: Final tumor weights were significantly lower in the shTCHP3 group compared to the NC group; D: Representative images of H&E staining of tumor tissues; E: Western blotting confirmed the knockdown of TCHP in the harvested tumors; F: The expression of Ki67 protein was detected by immunohistochemistry; G: Apoptosis in the subcutaneous xenograft model was assessed by the TUNEL assay. Data are presented as mean ± SD; n = 4 mice per group. ^aP < 0.05; ^bP < 0.01; ^cP < 0.001. NC: Negative control.