TCHP regulates the proliferation and apoptosis of gastric cancer cells via AKT/BCL2 signaling pathway

Figure 3 Proteomic analysis identifies differentially expressed proteins following TCHP knockdown. A: Principal component analysis demonstrates distinct clustering between negative and shTCHP3 groups; B: Volcano plot shows the distribution of differentially expressed proteins (DEPs); C: Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis reveals significant enrichment in metabolic and apoptosis pathways; D: Gene set enrichment analysis indicates a significant upregulation of the apoptosis pathway in TCHP-knockdown gastric cancer cells; E: A heatmap shows the expression levels of key DEPs in the apoptosis pathway; F: KEGG secondary enrichment analysis identifies significant enrichment of proteins in the PI3K/AKT pathway.