Synergistic value of systemic inflammatory and tumor markers in predicting pretreatment distant metastasis of gastric cancer

doi:10.4251/wjgo.120785

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Jul 15, 2026; 18(7): 120785
Published online Jul 15, 2026. doi: 10.4251/wjgo.120785

Table 4 Performance of the combined predictive model and individual indicators for predicting distant metastasis in gastric cancer

	Cut-off	AUC	Sensitivity	Specificity	Youden index
Training set
CA19-9	22.9	0.732	0.638	0.872	0.510
NE	4.75	0.731	0.448	0.947	0.395
LY	1.4	0.687	0.672	0.606	0.278
Antrum	-	0.651	0.672	0.628	0.300
Model	0.337	0.888	0.776	0.819	0.595
Validation set
CA19-9	8.49	0.696	0.714	0.590	0.308
NE	6.09	0.781	0.633	0.872	0.504
LY	1.3	0.721	0.694	0.679	0.627
Antrum	-	0.683	0.674	0.693	0.373
Model	0.311	0.896	0.898	0.718	0.616

CA19-9: Carbohydrate antigen 19-9; NE: Neutrophils; LY: Lymphocytes.

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Citation: Shen YM, Hong XY, Gao HC, Hao QL, Li ZY, Yao ZY, Gao C. Synergistic value of systemic inflammatory and tumor markers in predicting pretreatment distant metastasis of gastric cancer. World J Gastrointest Oncol 2026; 18(7): 120785
URL: https://www.wjgnet.com/1948-5204/full/v18/i7/120785.htm
DOI: https://dx.doi.org/10.4251/wjgo.120785

Shen YM, Hong XY, Gao HC, Hao QL, Li ZY, Yao ZY, Gao C. Synergistic value of systemic inflammatory and tumor markers in predicting pretreatment distant metastasis of gastric cancer. World J Gastrointest Oncol 2026; 18(7): 120785 [DOI: 10.4251/wjgo.120785]

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