Impact of textbook outcome after hepatectomy for colorectal metastases on salvage curative-intent treatment at recurrence

Table 4 Effect of risk factors on salvage curative-intent treatment by univariable and multivariable analysis

Variables	Univariate		Multivariate
	P value	OR (95%CI)	P value	OR (95%CI)
Gender, male	0.423	1.27 (0.71-2.30)
Age, ≥ 60 years	0.461	0.81 (0.45-1.43)
BMI, ≥ 24 kg/m2	0.845	0.94 (0.53-1.68)
Hypertension	0.838	0.94 (0.52-1.69)
Diabetes	0.121	1.99 (0.83-4.77)
Tumor grade, high	0.901	1.04 (0.54-2.00)
Laparoscopic	0.005	2.89 (1.38-6.04)	0.175	1.77 (0.78-4.02)
Major hepatectomy	0.029	0.19 (0.04-0.85)	0.098	0.26 (0.05-1.28)
Neoadjuvant therapy	0.066	1.71 (0.97-3.04)	0.352	1.35 (0.72-2.51)
Primary tumor location, colon	0.793	1.08 (0.61-1.91)
Lymph nodal metastasis	0.389	1.32 (0.70-2.48)
Synchronous	0.389	1.32 (0.70-2.48)
Multiple	0.416	1.27 (0.71-2.26)
Bilobar	0.558	1.19 (0.66-2.16)
Max diameter, > 3 cm	0.051	0.56 (0.32-1.00)	0.372	0.75 (0.39-1.42)
CEA, ≥ 10 ng/mL	0.806	1.07 (0.61-1.90)
Simultaneous resection	0.034	0.50 (0.26-0.95)	0.255	0.65 (0.31-1.36)
Adjuvant therapy	0.671	1.16 (0.59-2.26)
ASA, class III	0.647	1.25 (0.48-3.26)
TO	< 0.001	5.43 (2.49-11.84)	0.003	3.54 (1.52-8.25)

OR: Odds ratio; CI: Confidence interval; BMI: Body mass index; CEA: Carcinoembryonic antigen; ASA: American Society of Anesthesiologists physical status; TO: Textbook outcome.