Prognostic significance of germline ARID5B and LEPR polymorphisms in intrahepatic and perihilar cholangiocarcinoma after curative resection

doi:10.4251/wjgo.120469

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World Journal of Gastrointestinal Oncology

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1948-5204

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World J Gastrointest Oncol. Jul 15, 2026; 18(7): 120469
Published online Jul 15, 2026. doi: 10.4251/wjgo.120469

Table 5 Multivariable Cox regression analysis of recurrence-free survival, cancer-specific survival and overall survival in perihilar cholangiocarcinoma

Variables	Recurrence-free survival		Cancer-specific survival		Overall survival
Variables	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value
Hemoglobin, g/L (≤ 12 = 1)	0.274 (0.146-0.516)	< 0.001	0.347 (0.180-0.668)	0.002	0.385 (0.226-0.654)	< 0.001
Intraoperative FFP (no = 1)	2.868 (1.501-5.480)	0.001	4.340 (2.094-8.994)	< 0.001	3.072 (1.762-3.354)	< 0.001
MVI (no = 1)	48.237 (8.791-264.662)	< 0.001	50.516 (8.685-293.835)	< 0.001	19.083 (3.880-93.844)	< 0.001
Tumor grading (G1/G2 = 1)	3.740 (1.711-8.177)	< 0.001	4.637 (2.109-10.193)	< 0.001	3.699 (1.879-7.284)	< 0.001
pT category (pT1-2 = 1)			2.573 (1.358-4.877)	0.004	2.227 (1.309-3.789)	0.003
N category (pN0 = 1)	2.704 (1.476-4.954)	0.001	2.524 (1.374-4.634)	0.003	1.779 (1.055-2.998)	0.031
Perioperative complications (Clavien-Dindo) (0/I/II = 1)					2.115 (1.279-3.497)	0.004

Only significant parameters are shown. FFP: Fresh frozen plasma; MVI: Microvascular invasion; CI: Confidence interval; HR: Hazard ratio.

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Citation: Wang G, Otto C, Liu D, Al-Masri TM, Lueong SS, Siveke J, Luedde T, Heise D, Vondran FW, Meister FA, Lurje G, Neumann U, Heij L, Bednarsch J. Prognostic significance of germline ARID5B and LEPR polymorphisms in intrahepatic and perihilar cholangiocarcinoma after curative resection. World J Gastrointest Oncol 2026; 18(7): 120469
URL: https://www.wjgnet.com/1948-5204/full/v18/i7/120469.htm
DOI: https://dx.doi.org/10.4251/wjgo.120469

Wang G, Otto C, Liu D, Al-Masri TM, Lueong SS, Siveke J, Luedde T, Heise D, Vondran FW, Meister FA, Lurje G, Neumann U, Heij L, Bednarsch J. Prognostic significance of germline ARID5B and LEPR polymorphisms in intrahepatic and perihilar cholangiocarcinoma after curative resection. World J Gastrointest Oncol 2026; 18(7): 120469 [DOI: 10.4251/wjgo.120469]

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