Prognostic significance of germline ARID5B and LEPR polymorphisms in intrahepatic and perihilar cholangiocarcinoma after curative resection

Table 4 Single nucleotide polymorphism frequencies and associations with recurrence-free survival, cancer-specific survival and overall survival in perihilar cholangiocarcinoma

SNP	n (%)	Recurrence-free survival				Cancer-specific survival				Overall survival
		Median (95%CI)	P value1	HR (95%CI)	P value2	Median (95%CI)	P value1	HR (95%CI)	P value2	Median (95%CI)	P value1	HR (95%CI)	P value2
Recessive model
rs10740055			0.027				0.004				< 0.001
CC/CA	85 (72.6)	52 (22.1-81.9)		1		65 (31.8-98.2)		1		50 (38.7-61.3)		1
AA	32 (27.4)	15 (9.4-20.6)		1.840 (1.057-3.200)	0.031	19 (8.7-29.3)		2.184 (1.262-3.781)	0.005	14 (8.5-19.5)		1.840 (1.057-3.200)	0.001
rs1137101			0.460				0.843				0.647
AA/AG	92 (78.7)	31 (15.8-46.2)		1		45 (28.5-61.5)		1		32 (22.2-41.8)		1
GG	25 (21.4)	52 (25.0-79.0)		0.790 (0.420-1.486)	0.464	63 (19.4-106.6)		0.941 (0.516-1.718)	0.844	54 (13.8-94.2)		0.890 (0.537-1.473)	0.650
rs3184504			0.072				0.070				0.423
TT/TC	92 (78.6)	52 (18.6-85.4)		1		63 (36.0-90.0)		1		39 (22.5-55.5)		1
CC	32 (27.4)	19 (10.1-27.9)		1.618 (0.949-2.758)	0.077	29 (16.8-41.2)		1.102 (0.625-1.941)	0.737	19 (7.0-31.0)		1.214 (0.752-1.960)	0.428
rs3130			0.841				0.934				0.448
TT/TC	79 (67.6)	31 (13.0-49.0)		1		50 (28.2-71.8)		1		32 (21.1-42.9)		1
CC	26 (22.2)	52 (0-106.2)		1 (0.999-1.001)	0.586	33 (0-87.3)		1.000 (0.999-1.001)	0.804	30 (0-69.7)		1.000 (0.999-1.000)	0.257
rs3748816			0.616				0.211				0.668
AA/AG	105 (89.7)	39 (23.6-54.4)		1		51 (28.3-73.7)		1		38 (22.8-53.2)		1
GG	12 (10.3)	24 (12.8-35.3)		1.207 (0.574-2.535)	0.620	28 (20.4-35.6)		1.562 (0.769-3.174)	0.217	26 (20.9-31.1)		1.154 (0.596-2.232)	0.672
rs7528484			0.626				0.793				0.343
CC/CT	100 (85.5)	36 (24.0-48.0)		1		50 (23.9-76.1)		1		38 (25.0-51.0)		1
TT	17 (14.5)	55 (8.4-101.6)		0.824 (0.375-1.810)	0.629	84 (0-235.9)		0.949 (0.451-1.998)	0.891	27 (4.1-49.6)		1.306 (0.747-2.281)	0.349
Co-dominant model
rs10740055			0.060				0.015				0.002
CC	32 (27.4)	42 (29.5-54.5)		1		76 (39.9-112.1)		1		63 (45.3-80.8)		1
CA	53 (45.3)	67 (18.7-115.3)		0.759 (0.423-1.363)	0.356	63 (23.3-102.7)		0.913 (0.494-1.685)	0.770	41 (22.1-60.0)		1.218 (0.719-2.064)	0.462
AA	32 (27.4)	15 (9.4-20.6)		1.582 (0.842-2.971)	0.154	19 (8.7-29.3)		2.070 (1.077-3.977)	0.029	14 (8.5-19.5)		2.467 (1.392-4.373)	0.002
rs1137101			0.626				0.962				0.842
AA	34 (29.1)	24 (0-49.8)		1		51 (0-106.3)		1		29 (7.4-50.6)		1
AG	58 (49.6)	42 (2.9-81.1)		0.842 (0.482-1.472)	0.547	45 (28.5-61.5)		1.061 (0.584-1.927)	0.847	32 (23.1-40.9)		1.096 (0.664-1.808)	0.721
GG	25 (21.4)	52 (25.0-79.0)		0.712 (0.350-1.450)	0.349	63 (19.4-106.6)		0.976 (0.480-1.985)	0.947	54 (13.8-94.2)		0.942 (0.519-1.709)	0.843
rs3184504			0.130				0.180				0.723
TT	28 (23.9)	83 (58.2-107.5)		1		80.2 (56.6-103.8)		1		38 (22.3-53.7)		1
TC	57 (48.7)	45 (18.5-71.5)		1.404 (0.707-2.787)	0.332	63 (30.2-95.8)		1.154 (0.588-2.264)	0.677	49 (27.3-70.7)		0.977 (0.579-1.649)	0.931
CC	32 (27.4)	19 (10.1-27.9)		2.058 (0.984-4.302)	0.055	29 (16.8-41.2)		1.798 (0.878-3.683)	0.109	19 (7.0-31.0)		1.195 (0.661-2.163)	0.556
rs3130			0.652				0.926				0.863
TT	34 (29.1)	78 (25.7-130.3)		1		45 (0-106.1)		1		28 (10.9-45.1)		1
TC	45 (38.5)	25 (5.3-44.7)		0.875 (0.590-1.299)	0.508	50 (34.4-65.6)		0.908 (0.458-1.801)	0.782	38 (15.9-60.1)		0.987 (0.591-1.647)	0.960
CC	26 (22.2)	52 (0-106.2)		1.164 (0.818-1.657)	0.398	33 (0-87.3)		1.200 (0.629-2.290)	0.580	30 (0-69.7)		0.859 (0.473-1.562)	0.619
rs3748816			0.373				0.217				0.589
AA	50 (42.7)	37 (19.9-54.1)		1		50 (22.8-77.2)		1		33 (20.2-45.7)		1
AG	55 (47.0)	42 (0-96.1)		0.702 (0.413-1.192)	0.190	78 (61.9-94.2)		0.708 (0.410-1.222)	0.215	49 (29.2-68.8)		0.808 (0.517-1.264)	0.351
GG	12 (10.3)	24 (12.8-35.3)		1.005 (0.459-2.199)	0.990	28 (20.4-35.6)		1.312 (0.619-2.785)	0.479	26 (21.0-31.1)		1.033 (0.515-2.071)	0.927
rs7528484			0.855				0.758				0.471
CC	36 (30.8)	40 (13.1-66.9)		1		50 (9.3-90.7)		1		41 (22.4-59.6)		1
CT	64 (54.7)	31 (14.4-47.6)		1.077 (0.626-1.854)	0.788	45 (24.8-65.2)		1.231 (0.701-2.162)	0.469	31 (16.2-45.8)		1.214 (0.749-1.968)	0.431
TT	17 (14.5)	55 (8.4-101.6)		0.862 (0.366-2.031)	0.735	65 (10.4-119.6)		1.079 (0.472-2.465)	0.858	27 (4.1-49.9)		1.470 (0.778-2.777)	0.236
Dominant model
rs10740055			0.936				0.506				0.081
CC	32 (27.4)	42 (29.5-54.5)		1		76 (39.9-112.1)		1		63 (45.2-80.8)		1
AA/CA	85 (72.7)	29 (13.4-44.6)		0.979 (0.583-1.646)	0.937	39 (23.5-54.4)		1.205 (0.693-2.095)	0.509	30 (23.0-37.0)		1.531 (0.941-2.491)	0.087
rs1137101			0.400				0.912				0.865
AA	34 (29.0)	24 (0-49.8)		1		28 (0-106.3)		1		29 (7.4-50.6)		1
GG/AG	83 (71.0)	42 (17.0-67.0)		0.800 (0.474-1.352)	0.405	14 (21.2-76.8)		0.992 (0.700-1.404)	0.963	33 (19.5-46.5)		1.041 (0.650-1.667)	0.866
rs3184504			0.150				0.344				0.863
TT	28 (23.9)	82.8 (58.2-107.5)		1		80.2 (56.6-103.8)		1		38 (22.3-53.7)		1
CC/TC	89 (76.1)			1.599 (0.834-3.065)	0.158	49 (22.0-76.0)		1.353 (0.719-2.545)	0.349	32 (16.5-47.5)		1.044 (0.638-1.707)	0.864
rs3130			0.636				0.878				0.504
TT	34 (29.1)	78 (25.7-130.3)		1		45 (0-106.1)		1		28 (10.9-45.1)		1
CC/TC	71 (60.7)	29 (11.8-46.2)		1 (0.999-1.001)	0.587	50 (29.5-70.5)		1.000 (0.999-1.001)	0.804	38 (16.9-59.1)		1.000 (0.999-1.000)	0.258
rs3748816			0.262				0.408				0.436
AA	50 (42.7)	37 (19.9-54.1)		1		50 (22.8-77.2)		1		33 (20.3-45.7)		1
GG/AG	67 (57.3)	39 (0-83.3)		0.755 (0.460-1.240)	0.268	49 (12.4-85.6)		1.000 (0.999-1.001)	0.804	38 (20.3-55.7)		0.847 (0.555-1.293)	0.441
rs7528484			0.900				0.510				0.305
CC	36 (30.8)	40 (13.1-66.9)		1		50 (9.3-90.7)		1		41 (22.4-59.6)		1
TT/CT	81 (69.2)	36 (18.4-53.6)		1.034 (0.611-1.749)	0.901	49 (16.2-81.8)		1.199 (0.696-2.063)	0.513	31 (18.8-43.2)		1.269 (0.801-2.011)	0.310

¹Kaplan-Meier survival analysis.

²Univariate Cox regression analyses.

SNP: Single-nucleotide polymorphism; CI: Confidence interval; HR: Hazard ratio.