Prognostic significance of germline ARID5B and LEPR polymorphisms in intrahepatic and perihilar cholangiocarcinoma after curative resection

doi:10.4251/wjgo.120469

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World Journal of Gastrointestinal Oncology

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1948-5204

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World J Gastrointest Oncol. Jul 15, 2026; 18(7): 120469
Published online Jul 15, 2026. doi: 10.4251/wjgo.120469

Table 3 Multivariable Cox regression analysis of recurrence-free survival, cancer-specific survival and overall survival in intrahepatic cholangiocarcinoma

Variables	Recurrence-free survival		Cancer-specific survival		Overall survival
Variables	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value
Neoadjuvant therapy (no = 1)	5.346 (1.737-16.455)	0.003
LVI (no = 1)	3.749 (1.895-7.418)	< 0.001			5.524 (2.600-11.738)	< 0.001
Hemoglobin, g/L (≤ 12 = 1)			0.438 (0.222-0.867)	0.018	0.078 (0.013-0.486)	0.006
N category (pN0 = 1)			3.562 (1.802-7.041)	< 0.001
rs10740055 (CC/CA = 1)	2.413 (1.311-4.440)	0.005	2.265 (1.137-4.513)	0.020	4.095 (1.966-8.529)	< 0.001

Only significant parameters are shown. LVI: Lymph vascular invasion; CI: Confidence interval; HR: Hazard ratio.

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Citation: Wang G, Otto C, Liu D, Al-Masri TM, Lueong SS, Siveke J, Luedde T, Heise D, Vondran FW, Meister FA, Lurje G, Neumann U, Heij L, Bednarsch J. Prognostic significance of germline ARID5B and LEPR polymorphisms in intrahepatic and perihilar cholangiocarcinoma after curative resection. World J Gastrointest Oncol 2026; 18(7): 120469
URL: https://www.wjgnet.com/1948-5204/full/v18/i7/120469.htm
DOI: https://dx.doi.org/10.4251/wjgo.120469

Wang G, Otto C, Liu D, Al-Masri TM, Lueong SS, Siveke J, Luedde T, Heise D, Vondran FW, Meister FA, Lurje G, Neumann U, Heij L, Bednarsch J. Prognostic significance of germline ARID5B and LEPR polymorphisms in intrahepatic and perihilar cholangiocarcinoma after curative resection. World J Gastrointest Oncol 2026; 18(7): 120469 [DOI: 10.4251/wjgo.120469]

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