Prognostic significance of germline ARID5B and LEPR polymorphisms in intrahepatic and perihilar cholangiocarcinoma after curative resection

Table 2 Single nucleotide polymorphism frequencies and associations with recurrence-free survival, cancer-specific survival and overall survival in intrahepatic cholangiocarcinoma

SNP	n (%)	Recurrence-free survival				Cancer-specific survival				Overall survival
		Median (95%CI)	P value1	HR (95%CI)	P value2	Median (95%CI)	P value1	HR (95%CI)	P value2	Median (95%CI)	P value1	HR (95%CI)	P value2
Recessive model
rs10740055			0.013				0.029				0.018
CC/CA	85 (75.9)	13 (8.7-17.1)		1		30 (18.3-41.7)		1		28 (21.0-35.0)		1
AA	26 (23.2)	8 (3.9-12.1)		1.866 (1.116-3.121)	0.017	16 (8.3-26.7)		1.776 (1.046-3.015)	0.033	12 (3.0-21.0)		1.791 (1.093-2.932)	0.021
rs11168249			0.125				0.662				0.332
TT/TC	94 (84.0)	13 (8.3-17.7)		1		28 (15.4-40.6)		1		25 (17.5-32.5)		1
CC	18 (16.1)	7 (4.6-9.4)		1.602 (0.861-2.982)	0.137	31 (17.5-44.5)		1.154 (0.603-2.208)	0.665	24 (9.4-38.6)		1.328 (0.742-2.378)	0.339
rs1137101			0.007				0.107				0.221
AA/AG	83 (74.1)	16 (10.3-21.7)		1		36 (21.7-50.3)		1		29 (15.9-42.1)		1
GG	29 (25.9)	7 (6.2-7.8)		1.910 (1.170-3.116)	0.010	20 (12.2-27.8)		1.506 (0.907-2.500)	0.113	20 (13.0-27.0)		1.342 (0.833-2.164)	0.227
rs2736100			0.879				0.782				0.610
CC/CA	75 (67.0)	13 (7.0-19.0)		1		30 (19.2-40.8)		1		28 (17.3-38.7)		1
AA	29 (25.9)	11 (5.6-16.4)		1.043 (0.610-1.781)	0.878	29 (10.0-47.9)		0.922 (0.517-1.646)	0.784	20 (9.4-30.5)		1.139 (0.687-1.889)	0.613
rs3748816			0.513				0.581				0.390
AA/AG	93 (83.0)	12 (6.1-17.9)		1		28 (14.7-41.3)		1		25 (16.5-33.5)		1
GG	18 (16.1)	11 (4.8-17.2)		0.823 (0.453-1.496)	0.523	27 (20.1-33.9)		0.841 (0.451-1.568)	0.585	27 (20.1-33.9)		0.773 (0.426-1.402)	0.397
rs7528484			0.188				0.078				0.193
CC/CT	86 (76.8)	10 (5.5-14.5)		1		29 (19.7-38.3)		1		25 (19.3-30.7)		1
TT	26 (23.2)	15 (10.4-19.6)		0.691 (0.392-1.217)	0.201	21 (0-48.2)		0.601 (0.321-1.126)	0.112	32 (0-77.8)		0.699 (0.404-1.209)	0.200
Co-dominant model
rs10740055			0.034				0.093				0.060
CC	27 (24.1)	10 (5.1-14.9)		1		30 (6.5-53.5)		1		29 (11.9-46.1)		1
CA	58 (51.8)	16 (12.3-19.7)		1.275 (0.711-2.288)	0.415	31 (18.8-43.2)		1.007 (0.557-1.821)	0.981	28 (19.8-36.2)		0.987 (0.572-1.702)	0.962
AA	26 (23.2)	8 (3.9-12.1)		2.208 (1.138-4.286)	0.019	16 (8.3-23.7)		1.785 (0.917-3.475)	0.088	12 (3.0-21.0)		1.775 (0.957-3.289)	0.068
rs11168249			0.180				0.231				0.360
TT	33 (29.5)	8 (2.7-13.3)		1		20 (17.3-22.7)		1		20 (16.7-23.3)		1
TC	61 (54.5)	17 (11.3-22.7)		0.765 (0.462-1.268)	0.299	38 (22.6-53.4)		0.647 (0.385-1.087)	0.100	29 (16.3-41.7)		0.767 (0.469-1.254)	0.290
CC	18 (16.1)	7 (4.6-9.4)		1.353 (0.678-2.701)	0.391	31 (17.5-44.5)		0.880 (0.431-1.796)	0.726	24 (9.4-38.6)		1.121 (0.582-2.158)	0.733
rs1137101			0.014				0.262				0.452
AA	29 (25.9)	18 (0-48.5)		1		41 (21.5-60.5)		1		31 (7.6-54.4)		1
AG	54 (48.2)	13 (3.4-19.7)		1.445 (0.781-2.675)	0.241	30 (12.6-47.4)		1.102 (0.598-2.031)	0.755	28 (12.1-43.9)		0.919 (0.537-1.574)	0.760
GG	29 (25.9)	7 (6.2-7.8)		2.464 (1.268-4.790)	0.008	20 (12.2-27.8)		1.609 (0.832-3.111)	0.157	20 (13.0-27.0)		1.271 (0.706-2.290)	0.424
rs2736100			0.980				0.671				0.422
CC	31 (27.7)	11 (4.8-17.2)		1		22 (12.9-31.1)		1		20 (11.8-28.2)		1
CA	44 (39.3)	15 (8.9-21.1)		0.966 (0.559-1.670)	0.902	32 (20.3-43.7)		0.784 (0.442-1.391)	0.405	32 (20.3-43.7)		0.713 (0.414-1.230)	0.224
AA	29 (25.9)	11 (5.7-16.4)		1.022 (0.548-1.906)	0.946	29 (10.0-48.0)		0.792 (0.404-1.552)	0.497	20 (7.5-30.5)		0.924 (0.509-1.678)	0.795
rs3748816			0.282				0.639				0.688
AA	43 (38.4)	16 (8.4-23.6)		1		41 (17.9-64.1)		1		22 (1.0-43.0)		1
AG	50 (44.6)	8 (2.6-13.4)		1.432 (0.862-2.380)	0.166	25 (16.0-34.0)		1.224 (0.721-2.081)	0.454	25 (15.9-34.1)		0.978 (0.606-1.578)	0.926
GG	18 (16.1)	11 (4.8-17.2)		1.005 (0.514-1.965)	0.989	27 (20.1-33.9)		0.944 (0.469-1.900)	0.872	27 (20.1-33.9)		0.764 (0.399-1.462)	0.416
rs7528484			0.238				0.177				0.212
CC	32 (28.6)	18 (5.6-30.4)		1		30 (22.1-37.9)		1		28 (19.9-36.0)		1
CT	54 (48.2)	10 (5.1-14.9)		1.304 (0.775-2.194)	0.318	25 (19.2-30.9)		1.265 (0.740-2.163)	0.390	22 (13.9-30.1)		1.343 (0.806-2.239)	0.258
TT	26 (23.2)	15 (10.4-19.6)		0.807 (0.420-1.549)	0.519	86 (55.0-117.4)		0.693 (0.339-1.414)	0.313	32 (0-77.8)		0.831 (0.440-1.570)	0.569
Dominant model
rs10740055			0.152				0.536				0.549
CC	27 (24.1)	10 (5.1-14.9)		1		30 (6.5-53.5)		1		29 (11.9-46.1)		1
AA/CA	84 (75.0)	13 (7.1-18.9)		1.485 (0.851-2.590)	0.164	27 (17.5-36.5)		1.190 (0.681-2.081)	0.541	24 (17.5-30.5)		1.168 (0.699-1.952)	0.554
rs11168249			0.512				0.136				0.439
TT	33 (29.5)	8 (2.7-13.3)		1		20 (17.3-22.7)		1		20 (16.7-23.3)		1
CC/TC	79 (70.6)	13 (6.3-19.7)		0.855 (0.528-1.382)	0.522	31 (19.3-42.8)		0.692 (0.424-1.131)	0.142	28 (18.9-37.1)		0.833 (0.523-1.329)	0.444
rs1137101			0.059				0.424				0.902
AA	29 (25.9)	18 (0-48.5)		1		41 (21.5-60.5)		1		31 (7.6-54.4)		1
GG/AG	83 (74.1)	10 (6.5-13.5)		1.719 (0.960-3.079)	0.068	25 (18.0-32.0)		1.286 (0.917-1.803)	0.145	25 (17.9-32.1)		1.031 (0.627-1.698)	0.903
rs2736100			0.955				0.372				0.335
CC	31 (27.7)	11 (4.8-17.2)		1		22 (12.9-31.1)		1		20 (11.8-28.2)		1
AA/CA	73 (65.2)	12 (7.0-17.0)		0.986 (0.596-1.631)	0.956	32 (22.7-41.3)		0.787 (0.462-1.340)	0.377	29 (19.1-38.9)		0.786 (0.478-1.291)	0.341
rs3748816			0.287				0.613				0.682
AA	43 (38.4)	16 (8.4-23.6)		1		41 (17.9-64.1)		1		22 (1.0-43.0)		1
GG/AG	68 (60.7)	10 (5.8-14.2)		1.290 (0.798-2.086)	0.299	27 (22.0-32.0)		1.137 (0.688-1.877)	0.617	27 (22.4-37.6)		0.911 (0.581-1.428)	0.685
rs7528484			0.673				0.837				0.581
CC	32 (28.6)	18 (5.6-30.4)		1		30 (22.1-37.9)		1		28 (20.0-36.0)		1
TT/CT	80 (71.4)	11 (7.1-14.9)		1.109 (0.679-1.812)	0.680	27 (13.0-41.0)		1.055 (0.632-1.759)	0.838	24 (16.9-31.1)		1.144 (0.706-1.853)	0.585

¹Kaplan-Meier survival analysis.

²Univariate Cox regression analyses.

SNP: Single-nucleotide polymorphism; CI: Confidence interval; HR: Hazard ratio.