Chinese herbal medicine for colorectal cancer: An overview of systematic reviews and evidence map

Table 4 Summary of findings of evidence in administration of Chinese herbal medicine for colorectal cancer of unrestricted stage or status

Ref.	Details of PICO	Numbers of RCTs	Participants		Effect estimates	Quality of evidence
			Treatment	Control
KPS improvement rate
Wu[62]	Oral administration of CHM + chemotherapy for CC	15	529	492	OR = 3.81, 95%CI: 2.69-5.38	Low1,2
Zhao et al[61]	Oral administration of CHM + FOLFOX vs FOLFOX for CRC	8	248	233	RR = 2.20, 95%CI: 1.64-2.95	Low1,2
Wu et al[71]	SFI + chemotherapy vs chemotherapy for CRC	13	585	555	RR = 1.72, 95%CI: 1.49-1.99	Low1,2
Zhang et al[79]	SFI + FOLFOX vs FOLFOX for CRC	7	306	296	RR = 1.76, 95%CI: 1.40-2.23	Low1,2

¹Risk of bias of included trials.

²Clinical heterogeneity.

CHM: Chinese herbal medicine; PICO: Population Intervention Comparison Outcome; RCT: Randomized controlled trial; KPS: Karnofsky Performance Status; CRC: Colorectal cancer; CC: Colon cancer; SFI: Shenqi Fuzheng Injections; OR: Odds ratio; RR: Risk ratio; CI: Confidence interval.