Impact of anxiety and depression on quality of life in gastric cancer patients receiving SOX neoadjuvant chemotherapy

doi:10.4251/wjgo.119170

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Jul 15, 2026; 18(7): 119170
Published online Jul 15, 2026. doi: 10.4251/wjgo.119170

Table 2 Intergroup comparison of factors related to anxiety/depression, n (%)

Variables	Total (n = 153)	Normal group (n = 80)	Anxiety-depression group (n = 73)	Statistic	P value
Age	55.00 (40.00, 71.00)	54.50 (37.00, 72.25)	55.00 (41.00, 71.00)	Z = -0.43	0.665
Gender				χ² = 5.19	0.023
Male	94 (61.44)	56 (70.00)	38 (52.05)
Female	59 (38.56)	24 (30.00)	35 (47.95)
BMI, kg/m²	25.60 (21.00, 30.40)	26.45 (19.00, 30.40)	25.50 (21.40, 30.40)	Z = -0.11	0.914
Marital status				χ² = 6.25	0.012
Married	122 (79.74)	70 (87.50)	52 (71.23)
Unmarried/divorced/widowed	31 (20.26)	10 (12.50)	21 (28.77)
Educational level				χ² = 7.18	0.028
High school or above	33 (21.57)	23 (28.75)	10 (13.70)
Junior and senior high school	57 (37.25)	31 (38.75)	26 (35.62)
Primary school and below	63 (41.18)	26 (32.50)	37 (50.68)
Tumor size, cm	5.30 (2.90, 7.70)	4.70 (2.82, 8.03)	5.70 (3.50, 7.60)	Z = -0.50	0.621
Number of lymph node metastases	3.00 (2.00, 4.00)	3.00 (2.00, 4.00)	3.00 (2.00, 4.00)	Z = -0.25	0.799
Pathological type				χ² = 1.50	0.472
Others	24 (15.69)	12 (15.00)	12 (16.44)
Adenocarcinoma	105 (68.63)	58 (72.50)	47 (64.38)
Signet ring cell carcinoma	24 (15.69)	10 (12.50)	14 (19.18)
Differentiation grade				χ² = 3.79	0.285
Low differentiation	53 (34.64)	24 (30.00)	29 (39.73)
Highly differentiated	37 (24.18)	19 (23.75)	18 (24.66)
Undifferentiated	15 (9.80)	11 (13.75)	4 (5.48)
Moderate differentiation	48 (31.37)	26 (32.50)	22 (30.14)
HER2 status				χ² = 0.02	0.884
Positive	39 (25.49)	20 (25.00)	19 (26.03)
Negative	114 (74.51)	60 (75.00)	54 (73.97)
Clinical stage				χ² = 9.09	0.003
I/II	74 (48.37)	48 (60.00)	26 (35.62)
III	79 (51.63)	32 (40.00)	47 (64.38)

BMI: Body mass index; HER2: Human epidermal growth factor receptor 2.

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Citation: Cui BY, Zhang Z. Impact of anxiety and depression on quality of life in gastric cancer patients receiving SOX neoadjuvant chemotherapy. World J Gastrointest Oncol 2026; 18(7): 119170
URL: https://www.wjgnet.com/1948-5204/full/v18/i7/119170.htm
DOI: https://dx.doi.org/10.4251/wjgo.119170

Cui BY, Zhang Z. Impact of anxiety and depression on quality of life in gastric cancer patients receiving SOX neoadjuvant chemotherapy. World J Gastrointest Oncol 2026; 18(7): 119170 [DOI: 10.4251/wjgo.119170]

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