ST2, PIVKA-II, CEA, CA125 and their combinations in elderly liver metastases cancers: Development of a diagnostic scoring model

Table 6 Receiver operating characteristic curves analysis of soluble growth-stimulating gene 2, protein induced by vitamin K absence or antagonist-II, carcinoembryonic antigen, and carbohydrate antigen 125 individually and in combination

Project portfolio	AUC	Optimal cutoff value	Youden index	SE	95%CI	P value	Sensitivity (%)	Specificity (%)
ST2	0.641	32.48 pg/mL	0.276	0.045	0.553-0.729	0.003	72.46	55.19
PIVKA-II	0.668	42.02 mAU/mL	0.268	0.043	0.584-0.752	< 0.001	69.48	57.30
CEA	0.650	5.81 ng/mL	0.347	0.047	0.558-0.742	0.001	72.91	61.75
CA125	0.657	37.53 U/mL	0.251	0.046	0.567-0.747	< 0.001	65.36	59.72
ST2 + PIVKA-II	0.689	0.45	0.336	0.041	0.609-0.769	< 0.001	55.42	78.14
ST2 + CEA	0.624	0.42	0.342	0.049	0.528-0.720	< 0.001	56.34	77.89
ST2 + CA125	0.704	0.44	0.300	0.040	0.626-0.782	< 0.001	58.44	71.53
PIVKA-II + CEA	0.741	0.48	0.272	0.037	0.668-0.814	0.004	57.16	70.06
BEER-II + CA125	0.715	0.46	0.428	0.040	0.636-0.794	< 0.001	58.67	84.11
CEA + CA125	0.734	0.47	0.377	0.038	0.659-0.809	0.002	54.96	82.74
ST2 + PIVKA-II + CEA	0.660	0.52	0.420	0.041	0.580-0.740	< 0.001	49.37	92.66
ST2 + PIVKA-II + CA125	0.794	0.58	0.410	0.044	0.708-0.880	< 0.001	47.20	93.78
ST2 + CEA + CA125	0.817	0.62	0.402	0.047	0.725-0.909	< 0.001	46.05	94.19
PIVKA-II + CEA + CA125	0.863	0.65	0.409	0.049	0.767-0.959	< 0.001	44.42	96.47
ST2 + PIVKA-II + CEA + CA125	0.896	0.75	0.315	0.037	0.823-0.969	< 0.001	33.04	98.42

AUC: Area under the curve; ST2: Soluble growth-stimulating gene 2; PIVKA-II: Protein induced by vitamin K absence or antagonist-II; CEA: Carcinoembryonic antigen; CA125: Carbohydrate antigen 125.