Yiwei Xiaoyu granules mitigate spasmolytic polypeptide-expressing metaplasia-associated gastric mucosal damage by regulating WFDC2 and the miRNA-7/circRNA network

doi:10.4251/wjgo.118787

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Jul 15, 2026; 18(7): 118787
Published online Jul 15, 2026. doi: 10.4251/wjgo.118787

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Figure 7 Proposed schematic model of Yiwei Xiaoyu granules-mediated modulation of the miR-7a-5p-Cdr1as-WFDC2-cytokine axis in gastric mucosa. Arrow (↑): Activation or increase, blunt line (┤): Inhibition or decrease. YWXY: Yiwei Xiaoyu granules; Tam: Tamoxifen; SPEM: Spasmolytic polypeptide-expressing metaplasia. This figure was created by BioRender.com. https://BioRender.com/yezh7od.

Citation: Chen WQ, Xu YY, Pan HL, Duan M, Ma H, Li YP, Zhang JW. Yiwei Xiaoyu granules mitigate spasmolytic polypeptide-expressing metaplasia-associated gastric mucosal damage by regulating WFDC2 and the miRNA-7/circRNA network. World J Gastrointest Oncol 2026; 18(7): 118787
URL: https://www.wjgnet.com/1948-5204/full/v18/i7/118787.htm
DOI: https://dx.doi.org/10.4251/wjgo.118787

Chen WQ, Xu YY, Pan HL, Duan M, Ma H, Li YP, Zhang JW. Yiwei Xiaoyu granules mitigate spasmolytic polypeptide-expressing metaplasia-associated gastric mucosal damage by regulating WFDC2 and the miRNA-7/circRNA network. World J Gastrointest Oncol 2026; 18(7): 118787 [DOI: 10.4251/wjgo.118787]

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