Yiwei Xiaoyu granules mitigate spasmolytic polypeptide-expressing metaplasia-associated gastric mucosal damage by regulating WFDC2 and the miRNA-7/circRNA network

Figure 1 Simplified overview of the experimental design. A spleen-stomach deficiency syndrome associated gastric injury model was established using Xiao Chengqi decoction. Following model induction, mice received therapeutic intervention with Yiwei Xiaoyu granules, with or without tamoxifen administration. Gastric tissues were collected at predefined time points (days 15 and 30) for histological, immunofluorescence, and molecular analyses. Detailed treatment schedules and group allocations are provided in Supplementary Figure 1. SSDS: Spleen-stomach deficiency syndrome; XCQ: Xiao Chengqi decoction; YWXY: Yiwei Xiaoyu granules. This figure was created by http://biorender.comhttps://http://biorender.com/8ozzrx8.