Prophylactic sodium thiosulfate reduces the risk and severity of acute kidney injury in oxaliplatin-based hyperthermic intraperitoneal chemotherapy

doi:10.4251/wjgo.v18.i7.118400

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World Journal of Gastrointestinal Oncology

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1948-5204

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Retrospective Cohort Study

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World J Gastrointest Oncol. Jul 15, 2026; 18(7): 118400
Published online Jul 15, 2026. doi: 10.4251/wjgo.v18.i7.118400

Table 3 Postoperative serum creatinine and acute kidney injury stratified by prophylactic sodium thiosulfate

Variable	nST (n = 73)	ST (n = 46)	P value	OR (95%CI)
Peak postop creatinine median; (IQR)	114 (97-146)	92 (76-112)	< 0.001¹	N/A
Max relative increase in creatinine percentage median; (IQR)	63 (45-111)	40 (26-53)	< 0.001¹	N/A
Post op AKI	48 (66)	13 (28)	< 0.001²	0.21 (0.09-0.46)
Grade of AKI
No AKI	25 (34.2)	33 (71.7)	Reference	-
Grade 1	28 (38.4)	10 (21.7)	0.004²	0.27 (0.11-0.66)
Grade 2	17 (23.3)	3 (6.5)	0.003²	0.13 (0.04-0.51)
Grade 3	3 (4.1)	0 (0)	N/A³	N/A³

¹Mann-Whittney test.

²χ² test.

³Too few cases to be calculated.

nST: No sodium thiosulfate; ST: Sodium thiosulfate; AKI: Acute kidney injury; CI: Confidence interval; OR: Odds ratio; N/A: Not applicable; IQR: Interquartile range.

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Citation: Algethami N, Valdimarsson V, Verwaal V, Syk I. Prophylactic sodium thiosulfate reduces the risk and severity of acute kidney injury in oxaliplatin-based hyperthermic intraperitoneal chemotherapy. World J Gastrointest Oncol 2026; 18(7): 118400
URL: https://www.wjgnet.com/1948-5204/full/v18/i7/118400.htm
DOI: https://dx.doi.org/10.4251/wjgo.v18.i7.118400

Algethami N, Valdimarsson V, Verwaal V, Syk I. Prophylactic sodium thiosulfate reduces the risk and severity of acute kidney injury in oxaliplatin-based hyperthermic intraperitoneal chemotherapy. World J Gastrointest Oncol 2026; 18(7): 118400 [DOI: 10.4251/wjgo.v18.i7.118400]

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