Prophylactic sodium thiosulfate reduces the risk and severity of acute kidney injury in oxaliplatin-based hyperthermic intraperitoneal chemotherapy

Table 2 Perioperative characteristics, stratified on perioperative treatment with prophylactic sodium thiosulfate or no sodium thiosulfate, n (%)

Variable	nST (n = 73)	ST (n = 46)	P value
Reduced dose of intraperitoneal chemotherapy
No	41 (56)	41 (89)	< 0.0011
Yes	32 (44)	5 (11)
Length of operation	601 (523-690)	413 (351-488)	< 0.0012
Intraoperative bleeding	600 (350-800)	700 (413-1000)	0.122
Intraoperative hypotension4: Minutes5
0	40 (55)	22 (49)	Reference
< 0 - < 7.12	11 (15)	4 (9)	0.523
≥ 7.12	22 (30)	19 (42)	0.27
Inotropic support6
≤ 32 hours	44 (64)	28 (61)	0.751
> 32 hours	25 (36)	18 (39)
Peak postoperative lactate median; (IQR)	2.7 (2.2-3.1)	1.9 (1.6-2.4)	< 0.0012
GI anastomosis
0	31 (42)	16 (35)	Reference
1	32 (44)	25 (54)	0.313
2	5 (7)	4 (9)	0.55
> 2	5 (7)	1 (2)	0.41
Stoma formation
No	33 (45)	28 (61)	Reference
Yes	38 (52)	15 (33)	0.063
Has prior to surgery	2 (3)	3 (6)	0.55

¹χ² test.

²Mann-Whittney U test.

³Binary logistic regression analysis.

⁴< 80 mmHg.

⁵One missing patient.

⁶Four missing patients.

nST: No sodium thiosulfate; ST: Sodium thiosulfate; IQR: Interquartile range.