Duodenal signet-ring carcinoma arising in pyloric gland adenoma with RN7SL1/MUC6 upregulation and mitochondrial dysregulation: A case report

doi:10.4251/wjgo.117886

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Jul 15, 2026; 18(7): 117886
Published online Jul 15, 2026. doi: 10.4251/wjgo.117886

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Figure 1 Endoscopic and histologic findings of duodenal tumor. A: Polypoid lesion was found in the descending duodenum, presenting surface irregularity and hemorrhage; B and C: Low-power histology demonstrated closely packed pyloric gland-type tubules lined by a monolayer of cuboidal to low columnar epithelial cells with basally positioned round nuclei; D: High magnification examination revealed focal areas of signet ring cell carcinoma arising within the pyloric gland adenoma.

Citation: Wen X, Qiu JY, Li J, Mao ZR, Wu WQ. Duodenal signet-ring carcinoma arising in pyloric gland adenoma with RN7SL1/MUC6 upregulation and mitochondrial dysregulation: A case report. World J Gastrointest Oncol 2026; 18(7): 117886
URL: https://www.wjgnet.com/1948-5204/full/v18/i7/117886.htm
DOI: https://dx.doi.org/10.4251/wjgo.117886

Wen X, Qiu JY, Li J, Mao ZR, Wu WQ. Duodenal signet-ring carcinoma arising in pyloric gland adenoma with RN7SL1/MUC6 upregulation and mitochondrial dysregulation: A case report. World J Gastrointest Oncol 2026; 18(7): 117886 [DOI: 10.4251/wjgo.117886]

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