Cadherin 6 drives epithelial-mesenchymal transition and oxaliplatin resistance in gastric cancer via transforming growth factor-β/Smad signaling axis

doi:10.4251/wjgo.v18.i6.118121

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Jun 15, 2026; 18(6): 118121
Published online Jun 15, 2026. doi: 10.4251/wjgo.v18.i6.118121

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Figure 5 Immunohistochemistry of gastric cancer tissues. Immunohistochemistry verified that cadherin 6 overexpression exerted a synergistic effect to activate the transforming growth factor-β signaling pathway and induced epithelial-mesenchymal transition. ^aP < 0.05, ^bP < 0.01, and ^cP < 0.001. OE-CDH6: Cadherin 6-overexpression; CDH6: Cadherin 6; TGF-β: Transforming growth factor-β; PCNA: Proliferating cell nuclear antigen; IOD: Integrated optical density; IHC: Immunohistochemistry; ns: Not significant.

Citation: Zhao ZX, Liu QL, Fan JX, Zhu S, Wang FS, Hu ZJ. Cadherin 6 drives epithelial-mesenchymal transition and oxaliplatin resistance in gastric cancer via transforming growth factor-β/Smad signaling axis. World J Gastrointest Oncol 2026; 18(6): 118121
URL: https://www.wjgnet.com/1948-5204/full/v18/i6/118121.htm
DOI: https://dx.doi.org/10.4251/wjgo.v18.i6.118121

Zhao ZX, Liu QL, Fan JX, Zhu S, Wang FS, Hu ZJ. Cadherin 6 drives epithelial-mesenchymal transition and oxaliplatin resistance in gastric cancer via transforming growth factor-β/Smad signaling axis. World J Gastrointest Oncol 2026; 18(6): 118121 [DOI: 10.4251/wjgo.v18.i6.118121]

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